Activity of Essential Fatty Acid Elongation/Desaturation Pathway During Early Life in Human Infants, In Vivo

NCT00342303 | Completed

• 2 other identifiers: 999993027OH93-AA-N027
• Study Type: observational
• Target: 110
• Locations: 1 country
• Sites: 2

Brief Summary

We will test the following hypotheses:

1. 1.The activity of the desaturating/elongating enzymes assessed by the in vivo conversion of deuterated a-linolenic and linoleic acids to DHA and AA, respectively, will be related to the duration of gestation and to postnatal age.
2. 2.Dietary w-3 and w-6 LCPUFAs in human milk or DHA and AA supplemented formula will inhibit the desaturation/elongation of deuterated a-linolenic and linoleic acids demonstrating in vivo inhibition of the metabolic pathway by respective products.

Conditions

Fatty Acid Metabolism

Keywords

Premature Infants; Fatty Acid Metabolism; Polyunsaturated Fatty Acids; Infant Formula; Gas-chromatography; Mass Spectrometry

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Newborns with birth weights appropriate for their gestational age born at 28, 32, 36 and 40 weeks gestation that are recovering from common neonatal morbidity will be recruited to enter the study before 5 days of age. This disease condition will not be life threatening at the time of study.
• The typical disease conditions expected based on the pilot phase of study are infants recovering from asphyxia, infants recovering from transient tachypnea, infants recovering from suspect pneumonia, infants recovering from hyaline membrane disease.
• Newborns with birth weights below the tenth percentile of the weight distribution for a given gestational age born at 30-34 and 36-38 weeks gestation.
• Will include infants born at 28 to 40 weeks who are free of major neonatal morbidity and will be recruited to enter the study at 10 days of age.

You may not qualify if:

• Maternal factors which may affect their fatty acid metabolism of the neonate.
• Vegetarian or vegan diet during pregnancy
• Metabolic disease which may affect essential fatty acid status of the fetus (hyperlipidemia, diabetes)
• Postnatal factors:
• Birth weight inadequate for gestational age (birth weight below the 10th percentile or above the 90th percentile for gestational age)
• Significant acute neonatal morbidity which interferes with normal lipid metabolism during the study period. Infants who are recovering from common neonatal morbidities that do not have obvious effects on elongase/desaturase activity will not be excluded.
• Feeding other than prescribed for the study.

Sponsors & Collaborators

• National Institute on Alcohol Abuse and Alcoholism (NIAAA): lead

Study Sites (2)

Clinica Presbiteriana Madre Hijo

Santiago, Chile

Location

Hospital Luis Tisne

Santiago, Chile

Location

Related Publications (3)

• Lee AG, East JM, Froud RJ. Are essential fatty acids essential for membrane function? Prog Lipid Res. 1986;25(1-4):41-6. doi: 10.1016/0163-7827(86)90009-3. No abstract available.

  PMID: 2962202 BACKGROUND

• Glomset JA. Fish, fatty acids, and human health. N Engl J Med. 1985 May 9;312(19):1253-4. doi: 10.1056/NEJM198505093121909. No abstract available.

  PMID: 3990716 BACKGROUND

• Sprecher H. Biochemistry of essential fatty acids. Prog Lipid Res. 1981;20:13-22. doi: 10.1016/0163-7827(81)90009-6. No abstract available.

  PMID: 7342077 BACKGROUND

MeSH Terms

Conditions

Premature Birth

Condition Hierarchy (Ancestors)

Obstetric Labor, Premature; Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: June 19, 2006
• First Posted: June 21, 2006
• Study Start: June 8, 1993
• Study Completion: July 13, 2010
• Last Updated: July 2, 2017

Record last verified: 2010-07-13

Locations

CL (2)