Family Study of Head and Neck Cancers in Taiwan

NCT00342147 | Completed

• 2 other identifiers: 999995046OH95-C-N046
• Study Type: observational
• Target: 3,795
• Locations: 1 country
• Sites: 1

Brief Summary

Nasopharyngeal carcinoma is a rare tumor among Caucasians which occurs with high incidence among individuals of Chinese descent. The disease is believed to have a multifactorial etiology with genetic, viral, and other environmental factors being involved. Little is known, however, about the genetic component of this disease. We have recently completed subject recruitment for a case-control study of NPC in Taiwan. Using information obtained from the NPC cases recruited into this NCI-sponsored case-control study as well as from a parallel cross-sectional study conducted by our Taiwanese collaborators, we have been able to identify 120-150 families with multiple family members affected with NPC. The purpose of the study described herein is to determine the role of inherited genetic factors in the etiology of NPC and to examine the effect of these genetic susceptibility factors on risk associated with environmental exposures. Families will initially be contacted via the proband who previously participated in our case-control and cross-sectional studies. Subsequently, informative family members will be asked to visit the study clinic to participate in the study. A family history questionnaire will be administered to the proband from each of the families selected for study. In addition, a risk factor questionnaire will be administered to all participating family members, and 30-40 ml of blood and an oral sample will be obtained from each study participant. Additional study components include medical record review to verify the diagnosis of NPC, retrieval of tumor tissue blocks as a source of DNA for study, and clinical exams on a sample of unaffected individuals to exclude the possibility of prevalent, undetected disease among family members. Oral and laryngeal cancer families will also be recruited in a manner similar to that described for NPC families, in an attempt to elucidate genetic factors linked to the development of these two cancers....

Conditions

Nasopharyngeal Neoplasms; Herpesvirus 4, Human

Keywords

EBV; NPC

Outcome Measures

Primary Outcomes (1)

• Nasopharyngeal Carcinoma

  Nasopharyngeal carcinoma diagnosis

  Ongoing

Study Arms (1)

1

This is a high risk population of families for NPC

Eligibility Criteria

• Age: 18 Years - 99 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This is a high risk population of families for NPC

You may qualify if:

• Subjects with head and neck cancer who are participants in the case-control study of NPC or the parallel studies of head and neck cancers conducted by the Taiwanese.
• Subjects who report one or more first degree family members affected with NPC, oral cancer, or laryngeal cancer.

Sponsors & Collaborators

• National Cancer Institute (NCI): lead

Study Sites (1)

National Taiwan University College of Medicine

Taipei, Taiwan, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

Specimens collected: blood and saliva.

MeSH Terms

Conditions

Nasopharyngeal Neoplasms; Epstein-Barr Virus Infections

Condition Hierarchy (Ancestors)

Pharyngeal Neoplasms; Otorhinolaryngologic Neoplasms; Head and Neck Neoplasms; Neoplasms by Site; Neoplasms; Nasopharyngeal Diseases; Pharyngeal Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases; Herpesviridae Infections; DNA Virus Infections; Virus Diseases; Infections; Tumor Virus Infections

Study Officials

• Allan Hildesheim, Ph.D.

  National Cancer Institute (NCI)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 19, 2006
• First Posted: June 21, 2006
• Study Start: November 7, 1995
• Primary Completion: May 31, 2020
• Study Completion: June 5, 2020
• Last Updated: December 11, 2020

Record last verified: 2020-12

Locations

CN (1)