NCT00341315|Completed
Breast Cancer, Breast Disease, and Pesticides
A Study of Breast Cancer, Breast Disease, Mammographic Density and Pesticides Among a Population From Triana, Alabama
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A Study of Breast Cancer, Breast Disease, Mammographic Density and Pesticides Among a Population From Triana, Alabama
Sponsor study identifier
Secondary identifiers
observational
228
1 country
1
Study Start
May 17, 2004
Actual (reported)Primary Completion
April 18, 2020
Actual (reported)Study Completion
April 30, 2020
Actual (reported)This study will collect information on the height and weight of women who participated in a 1998 study in Triana, Alabama, on the risk of breast cancer and benign breast disease in relation to environmental exposure to the pesticide DDT and similar chemicals. This additional information is needed to calculate the participants' body mass index (BMI), which is required for completing analysis of the data. The 1998 study-a collaborative effort of the National Cancer Institute, the Triana Area Medical Fund, and the College of Nursing at the University of Alabama at Huntsville-investigated possible effects of DDT and other compounds on the risk of breast cancer, predominantly among African-American women in the area of Triana, Alabama. The study was initiated as a result of medical findings showing high blood levels of DDT among the local population who had consumed fish from a tributary of the Tennessee River that had been polluted by the discharge over several decades of large quantities of pesticides from a DDT production plant. Women participating in the study had a mammogram, physical examination, breast examination, and blood draw, and completed a questionnaire on diet and lifestyle factors. In order to complete analysis of the data and determine whether there is an association between environmental exposure to DDT and related chemicals and breast cancer risk, additional information on BMI is required.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 30, 2020
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
May 17, 2004
Actual (reported)June 19, 2006
Actual (reported)June 21, 2006
Actual (reported)April 18, 2020
Actual (reported)April 30, 2020
Actual (reported)DDT & DDE pesticide levels in blood
The objective is to evaluate the risk of breast cancer associated with organochlorines exposures among predominatly African- American women. This project is comprised of two major components (1) comparison of blood serum levels of DDT, DDE and other organochlorines compounds among members of the Triana Area Medical Fund population with a high percentage of mammographic densities to women without this condition and (2) methodologic investigations on organochlorines retention/decay patterns within the well-characterized Triana Area Fund population.
10 years +
Mammogram
10 years +
A primarily African-American population living in the vicinity of a DDT production plant inAlabama.
A primarily African-American population living in the vicinity of a DDT production plant in Alabama.
Contact the study team to confirm eligibility.
University of Alabama
Birmingham, Alabama, 35233, United States
Falck F Jr, Ricci A Jr, Wolff MS, Godbold J, Deckers P. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch Environ Health. 1992 Mar-Apr;47(2):143-6.
Kreiss K, Zack MM, Kimbrough RD, Needham LL, Smrek AL, Jones BT. Cross-sectional study of a community with exceptional exposure to DDT. JAMA. 1981 May 15;245(19):1926-30.
Krieger N, Wolff MS, Hiatt RA, Rivera M, Vogelman J, Orentreich N. Breast cancer and serum organochlorines: a prospective study among white, black, and Asian women. J Natl Cancer Inst. 1994 Apr 20;86(8):589-99. doi: 10.1093/jnci/86.8.589.
Robert N Hoover, M.D.
National Cancer Institute (NCI)
228 participants (actual enrollment reported by the registry).
First Submitted
June 19, 2006
First Posted
June 21, 2006
Study Start
May 17, 2004
Actual (reported)Sulindac in Preventing Breast Cancer in Women at High Risk for Breast Cancer
Tipifarnib Plus Tamoxifen in Treating Women With Metastatic Breast Cancer
Primary Completion
April 18, 2020
Actual (reported)Study Completion
April 30, 2020
Actual (reported)Last Updated
May 1, 2020
Record last verified: 2020-04
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