Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s)

NCT00341146 | Completed

• 2 other identifiers: 99990205602-C-N056
• Study Type: observational
• Target: 6,490
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this study is to characterize genes associated either with susceptibility or resistance to the development nasopharyngeal carcinoma (NPC) in a Chinese population where the incidence of NPC is as high as 50 in 100,000. NPC has been and remains a unique model of human malignancy for understanding a multi-step carcinogenic process involving a ubiquitous virus (Epstein-Barr virus), environmental carcinogens, and an NPC susceptibility gene. Up to 95% of all NPC patients at early or late stage of the disease have IgA antibodies directed to the EBV virus VCA (viral capsid antigen). Environmental factors have also been implicated as significant risk factors in the development of NPC. In addition, certain alleles in HLA genes have shown associations with NPC, perhaps in concert with a family of T-cell receptor genes (TCR). Other data suggest that a microsatellite marker on Chromosome 6 may be associated with an NPC-disease associated gene.

Conditions

Nasopharyngeal Carcinoma

Keywords

Cancer; Catonese Chinese; Genetic Predisposition; Genotyping; Triad analysis; Nasopharyngeal Cancer; NPC

Outcome Measures

Primary Outcomes (1)

• Collection from 9100 participants

  DNA Genotyping

  2006

Eligibility Criteria

• Age: 7 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Chinese population with a high incidence of NPC

You may qualify if:

• Individuals must meet the following eligibility criteria to be entered into the NPC study.
• Cohort A: Proband: NPC positive (stage III or IV), age less than 50 at time of NPC diagnosis, and EBV/IgA/VCA positive. Spouse of Proband. Child of proband and of spouse (or a parent of the proband)
• Cohort B: EBV/IgA/VCA positive 12 years ago and NPC negative. Spouse of proband. Child of proband and of spouse (or a parent of the proband).

You may not qualify if:

• Persons with any of the following will be excluded from the study.
• Persons who are unwilling or unable to given informed consent, or whose spouse and child(ren) (or parent) are willing to participate and give informed consent/assent.
• Persons with no living spouse of child(ren)/parent.

Sponsors & Collaborators

• National Cancer Institute (NCI): lead

Study Sites (1)

Institute for Viral Disease Control & Prevention

Beijing, China

Location

Related Publications (2)

• O'Brien SJ, Nelson GW, Winkler CA, Smith MW. Polygenic and multifactorial disease gene association in man: Lessons from AIDS. Annu Rev Genet. 2000;34:563-591. doi: 10.1146/annurev.genet.34.1.563.

  PMID: 11092839 BACKGROUND

• Zeng Y. Seroepidemiological studies on nasopharyngeal carcinoma in China. Adv Cancer Res. 1985;44:121-38. doi: 10.1016/s0065-230x(08)60027-5. No abstract available.

  PMID: 2994402 BACKGROUND

MeSH Terms

Conditions

Nasopharyngeal Carcinoma; Neoplasms; Genetic Predisposition to Disease; Nasopharyngeal Neoplasms

Condition Hierarchy (Ancestors)

Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Pharyngeal Neoplasms; Otorhinolaryngologic Neoplasms; Head and Neck Neoplasms; Neoplasms by Site; Nasopharyngeal Diseases; Pharyngeal Diseases; Stomatognathic Diseases; Otorhinolaryngologic Diseases; Disease Susceptibility; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Daniel W McVicar, Ph.D.

  National Cancer Institute (NCI)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 19, 2006
• First Posted: June 21, 2006
• Study Start: April 1, 2001
• Primary Completion: August 20, 2006
• Study Completion: September 20, 2006
• Last Updated: June 16, 2020

Record last verified: 2020-06

Locations

CN (1)