Genetic Susceptibility to Childhood Respiratory IIlness in Mexico City

NCT00339521 | Completed

• 2 other identifiers: 999999028OH99-E-N028
• Study Type: observational
• Target: 2,362
• Locations: 1 country
• Sites: 1

Brief Summary

We propose to add a collection of genetic material to a clinical trial of anti-oxidant supplementation for the amelioration of asthma in 7-12 year olds being conducted at a public pediatric hospital in Mexico City. The anti-oxidant study has been approved by the Institutional Review Board of the National Institute of Public Health in Mexico City and is scheduled to begin in September 1998. The purpose of this add-on study is to examine genetic polymorphisms that may be related to asthma. Asthma cases will be compared with their parents as controls. In partaicular, we will save the buffy coat from the blood collection being done on the asthmatic child for measurements of plasma micronutrients in the anti-oxidant trial for extraction of DNA. This part of the sample would otherwise be discarded. In addition, we will enroll the parents of the asthmatic child as controls for the child. From the parents, either a 10 ml blood sample or if they prefer, a sample of buccal cells will be collected. Although our current plan is to compare the asthmatic child to the parents using statistical methods based on the "transmission disequilibrium test" because research into various family designs for candidate gene studies is rapidly evolving and various sibling control sample strategies have been discussed, we would also like to collect a genetic sample on as many of the child's siblings as possible with priority given to those closest in age. This will enhance the future usefulness of the samples. We anticipate enrolling approximately 200 families....

Conditions

Asthma

Keywords

Asthma; Mexico; Triads; Polymorphism; Genetic Predisposition

Outcome Measures

Primary Outcomes (1)

• To create a resource to examine genetic susceptibility to asthma in Mexico City.

  The role of asthma candidate genes in the association between ozone exposure and asthma incidence.

  End of Study

Study Arms (1)

Case-Parent Triad

Childhood Asthmatics (aged 4-17) are Cases; biologic parents of cases are genetic Controls.

Eligibility Criteria

• Age: 4 Years - 17 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Asthmatic children registered at the allergy clinic of the Pediatric Hospital Frederico Gomez in Mexico City and their biological parents.

You may qualify if:

• Moderate to severe asthma, ages 7-12 and residing within 5 km of a particular ambient air pollution monitoring station.

Sponsors & Collaborators

• National Institute of Environmental Health Sciences (NIEHS): lead

Study Sites (1)

Hospital Infantil de Mexico Federico Gomez

Mexico City, Mexico

Location

Related Publications (3)

• Sandford A, Weir T, Pare P. The genetics of asthma. Am J Respir Crit Care Med. 1996 Jun;153(6 Pt 1):1749-65. doi: 10.1164/ajrccm.153.6.8665031.

  PMID: 8665031 BACKGROUND

• Hopes E, McDougall C, Christie G, Dewar J, Wheatley A, Hall IP, Helms PJ. Association of glutamine 27 polymorphism of beta 2 adrenoceptor with reported childhood asthma: population based study. BMJ. 1998 Feb 28;316(7132):664. doi: 10.1136/bmj.316.7132.664. No abstract available.

  PMID: 9522789 BACKGROUND

• Slutsky AS, Zamel N. Genetics of asthma: the University of Toronto Program. University of Toronto Genetics of Asthma Research Group. Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 2):S130-2. doi: 10.1164/ajrccm.156.4.12tac-10.

  PMID: 9351593 BACKGROUND

MeSH Terms

Conditions

Asthma; Genetic Predisposition to Disease

Condition Hierarchy (Ancestors)

Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Disease Susceptibility; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Stephanie London, M.D.

  National Institute of Environmental Health Sciences (NIEHS)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 19, 2006
• First Posted: June 21, 2006
• Study Start: May 15, 1999
• Primary Completion: February 12, 2007
• Study Completion: December 3, 2020
• Last Updated: December 4, 2020

Record last verified: 2020-12

Locations

ME (1)