Incidence and Mortality of Childhood Cancer Among Children of Farmer Pesticide Applications
2 other identifiers
observational
21,985
1 country
3
Brief Summary
Previous studies have estabished pesticide exposure as a possible risk factor for childhood cancer. The Agricultural Health Study (AHS), a prospective cohort study of pesticide exposure among 51,000 pesticide applicators in North Carolina and Iowa, provides an opportunity to study childhood cancer incidence and mortality among the children of pesticide applicators. Name and dates of birth for 21,985 children were previously provided by adult participants in the AHS. The current study seeks to identify cases of cancer among these children through record linkage to state cancer and death registries. Cancer incidence and mortality within the cohort will be compared with national data through standardized incidence and mortality ratios. A limited case-cohort comparison of pesticide exposures will also be performed. Approximately 44 cases of childhood cancer are expected to be identified. No follow-up or contact with cases is anticipated. It is anticipated that the study results will provide insight into the relationship of pesticide and other farm exposures to the pathogenesis of childhood cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2000
Longer than P75 for all trials
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 28, 2000
CompletedFirst Submitted
Initial submission to the registry
June 19, 2006
CompletedFirst Posted
Study publicly available on registry
June 21, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
June 11, 2007
CompletedJuly 2, 2017
June 11, 2007
June 19, 2006
June 30, 2017
Conditions
Keywords
Eligibility Criteria
You may qualify if:
- Subjects will be included in the study if they are children of private pesticide applicators who participated in the AHS, and were born between 1975 and 1996.
You may not qualify if:
- Subjects with age greater than 19 years during this period will be excluded as the outcome under study is childhood cancer.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
National Cancer Institute
Bethesda, Maryland, 20892, United States
NIEHS, Research Triangle Park
Research Triangle Park, North Carolina, 27709, United States
Environmental Protection Agency
Research Triangle Park, North Carolina, 27711, United States
Study Design
- Study Type
- observational
- Sponsor Type
- NIH
Study Record Dates
First Submitted
June 19, 2006
First Posted
June 21, 2006
Study Start
June 28, 2000
Study Completion
June 11, 2007
Last Updated
July 2, 2017
Record last verified: 2007-06-11