Neuroendocrine Dysfunction in Traumatic Brain Injury: Correlation With Cognitive Dysfunction and Repair

NCT00336726 | Terminated

• 1 other identifier: GR-735
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

Traumatic Brain Injury (TBI) is a neurologic disorder cuased by physical trauma to the brain. Neuroendocrine abnormalities in these patients have been reported, including central hypogonadism within hours of the insult and eventual recovery of the hypothalamic-pituitary-gonadal axis with recovery of cognitive function to baseline. This pilot study will measure hormonal level of neuroendocine function at the time of TBI and various time points during recovery.

Conditions

Traumatic Brain Injury

Eligibility Criteria

• Age: 21 Years - 65 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Male subjects having had a recent traumatic brain injury

You may qualify if:

• Male subjects having had a recent traumatic brain injury.

You may not qualify if:

• Currently receivng sex steroids, glucocorticoids, or have an inability to complete the neurobehavioral assessment.

Sponsors & Collaborators

• Denver Research Institute: lead

MeSH Terms

Conditions

Brain Injuries, Traumatic

Condition Hierarchy (Ancestors)

Brain Injuries; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Study Officials

• Margaret E Wierman, MD

  Dept. of Veterans Affairs/University of Colorado HSC

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: June 13, 2006
• First Posted: June 14, 2006
• Last Updated: March 24, 2011

Record last verified: 2004-12