NCT00330967|CompletedResults
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Sponsor study identifier
observational
25
1 country
1
Study Start
April 2006
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
January 2012
Actual (reported)Study Completion
August 2014
Actual (reported)The Objectives of the study are to: (1)compare the inflammatory response and insulin resistance in skeletal muscles during a systemic infusion of lipid with that during a local infusion of lipid into the femoral artery. which would cause minimal or no systemic hyperlipidemia but local plasma free fatty acid (FFA) concentrations similar to those during the systemic lipid infusion, and (2) determine the inflammatory response and insulin resistance in skeletal muscle during an infusion of lipid into the femoral artery as described above after NF-KB inhibition by high dose salicylate treatment in humans.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 2014
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 2006
Date type not reportedThis date has not been verified as actual or estimated.
May 26, 2006
Actual (reported)May 29, 2006
Actual (reported)January 2012
Actual (reported)August 2014
Actual (reported)March 17, 2015
Actual (reported)Insulin Signaling With Lipid Infusion
IRS-1 expression in response to femoral lipid infusion in skeletal muscle. Relative protein expression was calculated by densitometry analysis of Western blot bands, normalized to a housekeeping protein, GAPDH, in control and treated groups.
4 h
Phos-p38 MAPK Expression With Femoral Lipid and Insulin Infusions
Phosphorylation of p38 MAPK in response to femoral lipid and insulin infusions. phospho-p38 MAPK expression in response to femoral lipid infusion in skeletal muscle. Relative protein expression was calculated by densitometry analysis of Western blots, normalized to a housekeeping protein, GAPDH, of control and treated groups.
4 h
p38 MAPK Expression With Femoral Lipid and Insulin Infusions
healthy subjects
healthy subjects different from group 1
healthy subjects
Phoenix VA Health Care System Carl T. Hayden VA Medical Center, Phoenix, AZ
Phoenix, Arizona, 85012, United States
Blood samples, muscle biopsies
The study's original Principal Investigator left the VA prior to the completion of data acquisition and no further subjects were enrolled. The data entered were analyzed based solely on study files in the system.
Charles C Oh, MD
Phoenix VA Health Care System Carl T. Hayden VA Medical Center, Phoenix, AZ
25 participants (actual enrollment reported by the registry).
First Submitted
May 26, 2006
First Posted
May 29, 2006
Study Start
April 2006
Date type not reportedThis date has not been verified as actual or estimated.
Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver.
p38 MAPK expression in response to femoral lipid and insulin infusions in skeletal muscle. Relative protein expression was calculated by densitometry analysis of Western blots, normalized to a housekeeping protein, GAPDH, of control and treated groups.
4 h
Phospho-ERK MAPK Expression With Femoral Lipid and Insulin Infusions
Phosphorylation of ERK MAPK in response to femoral lipid and insulin infusions in skeletal muscle. Relative protein expression was calculated by densitometry analysis of Western blots, normalized to a housekeeping protein, GAPDH, of control and treated groups.
4 h
ERK MAPK Expression With Femoral Lipid and Insulin Infusions
ERK MAPK expression in response to femoral lipid and insulin infusions in skeletal muscle. Relative protein expression was calculated by densitometry analysis of Western blots, normalized to a housekeeping protein, GAPDH, of control and treated groups.
4 h
Phospho-JNK MAPK Expression With Femoral Lipid and Insulin Infusions
Phosphorylation of JNK MAPK in response to femoral lipid and insulin infusions in skeletal muscle. Relative protein expression was calculated by densitometry analysis of Western blots, normalized to a housekeeping protein, GAPDH, of control and treated groups.
4 h
JNK MAPK Expression With Femoral Lipid and Insulin Infusions
JNK MAPK expression in response to femoral lipid and insulin infusions in skeletal muscle. Relative protein expression was calculated by densitometry analysis of Western blots, normalized to a housekeeping protein, GAPDH, of control and treated groups.
4 h
Contact the study team to confirm eligibility.
Primary Completion
January 2012
Actual (reported)Study Completion
August 2014
Actual (reported)Last Updated
April 3, 2015
Results First Posted
March 17, 2015
Record last verified: 2015-03
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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