Open Label Study Assessing Effectiveness Of Amlodipine/Atorvastatin In Subjects With Hypertension and Dyslipidaemia
JEWEL I
An International, Multicentre, Open Label Study To Assess The Effectiveness Of Amlodipine -Atorvastatin Combination In Subjects With Hypertension and Dyslipidaemia. (The JEWEL Study)
1 other identifier
interventional
1,250
2 countries
125
Brief Summary
To evaluate the effectiveness of amlodipine/atorvastatin therapy by assessing the percentage of subjects who reach target blood pressure (BP) and LDL-C targets as defined by their governing guidelines.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3 hypertension
Started Oct 2004
Shorter than P25 for phase_3 hypertension
125 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2004
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2005
CompletedFirst Submitted
Initial submission to the registry
February 28, 2006
CompletedFirst Posted
Study publicly available on registry
May 29, 2006
CompletedJanuary 27, 2021
January 1, 2021
February 28, 2006
January 26, 2021
Conditions
Outcome Measures
Primary Outcomes (2)
To evaluate the number of patients who reach target blood pressure (BP) and
LDL-C targets as defined by their governing guidelines.
Secondary Outcomes (4)
To assess changes from baseline to end of treatment for the following efficacy
parameters: LDL-C, total cholesterol (TC), triglycerides, high-density lipoprotein
cholesterol (HDL-C), HDL-C/LDL-C ratio, TC/HDL-C ratio. Systolic Blood Pressure
(SBP) and Diastolic Blood Pressue (DBP).
Interventions
Eligibility Criteria
You may qualify if:
- Patients who are above target LDL-C and BP who are eligible for treatment
You may not qualify if:
- High liver enzymes
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (126)
Pfizer Investigational Site
Calgary, Alberta, T2N 2T8, Canada
Pfizer Investigational Site
Calgary, Alberta, T2N 4N1, Canada
Pfizer Investigational Site
Calgary, Alberta, T2S 3C3, Canada
Pfizer Investigational Site
Calgary, Alberta, T2X 3X7, Canada
Pfizer Investigational Site
Calgary, Alberta, T3E 7C4, Canada
Pfizer Investigational Site
Red Deer, Alberta, T4R 3J5, Canada
Pfizer Investigational Site
Campbell River, British Columbia, V9W 5Y4, Canada
Pfizer Investigational Site
Chilliwack, British Columbia, V2P 4M9, Canada
Pfizer Investigational Site
New Westminster, British Columbia, V3L 3W4, Canada
Pfizer Investigational Site
North Vancouver, British Columbia, V7N 4M2, Canada
Pfizer Investigational Site
Quesnel, British Columbia, V2J 2K3, Canada
Pfizer Investigational Site
Vancouver, British Columbia, V5K 1K3, Canada
Pfizer Investigational Site
Vancouver, British Columbia, V5P 3T7, Canada
Pfizer Investigational Site
Vancouver, British Columbia, V5Z 4E1, Canada
Pfizer Investigational Site
Vancouver, British Columbia, V6J 1Z6, Canada
Pfizer Investigational Site
Vancouver, British Columbia, V6M 3W7, Canada
Pfizer Investigational Site
Winnipeg, Manitoba, R2H 0R8, Canada
Pfizer Investigational Site
Winnipeg, Manitoba, R3A 1R9, Canada
Pfizer Investigational Site
Antigonish, Nova Scotia, B2G 2C2, Canada
Pfizer Investigational Site
Digby, Nova Scotia, B0V 1A0, Canada
Pfizer Investigational Site
Halifax, Nova Scotia, B3H 1V7, Canada
Pfizer Investigational Site
Halifax, Nova Scotia, B3K 5R3, Canada
Pfizer Investigational Site
Truro, Nova Scotia, B2N 1L2, Canada
Pfizer Investigational Site
Wolfville, Nova Scotia, B4P 1P4, Canada
Pfizer Investigational Site
Alymer, Ontario, N5H 1K9, Canada
Pfizer Investigational Site
Corunna, Ontario, N0N 1G0, Canada
Pfizer Investigational Site
Exeter, Ontario, Canada
Pfizer Investigational Site
Hamilton, Ontario, L8M 1K7, Canada
Pfizer Investigational Site
Kingston, Ontario, K7L 1C2, Canada
Pfizer Investigational Site
London, Ontario, N5W 1H4, Canada
Pfizer Investigational Site
London, Ontario, N5W 6A2, Canada
Pfizer Investigational Site
London, Ontario, N6A 4G5, Canada
Pfizer Investigational Site
London, Ontario, N6C 4Y7, Canada
Pfizer Investigational Site
London, Ontario, N6G 5A5, Canada
Pfizer Investigational Site
London, Ontario, N6H 4P2, Canada
Pfizer Investigational Site
London, Ontario, N6P 1A9, Canada
Pfizer Investigational Site
North York, Ontario, M2J 1W8, Canada
Pfizer Investigational Site
North York, Ontario, M3N 2V6, Canada
Pfizer Investigational Site
Oshawa, Ontario, L1H 1C5, Canada
Pfizer Investigational Site
Oshawa, Ontario, L1J 2K1, Canada
Pfizer Investigational Site
Peterborough, Ontario, K9H 5G1, Canada
Pfizer Investigational Site
Sarnia, Ontario, N7T 4X3, Canada
Pfizer Investigational Site
Toronto, Ontario, M4N 3M5, Canada
Pfizer Investigational Site
Toronto, Ontario, M4S 1Y2, Canada
Pfizer Investigational Site
Toronto, Ontario, M5G 2C4, Canada
Pfizer Investigational Site
Toronto, Ontario, M5T 3A9, Canada
Pfizer Investigational Site
Waterloo, Ontario, N2J 1C4, Canada
Pfizer Investigational Site
Weston, Ontario, M9N 1W4, Canada
Pfizer Investigational Site
Whitby, Ontario, L1N 5R5, Canada
Pfizer Investigational Site
Charlottetown, Prince Edward Island, C1A 5N4, Canada
Pfizer Investigational Site
Bonaventure, Quebec, GOC 1E0, Canada
Pfizer Investigational Site
Chomedy, Quebec, H7T 2P5, Canada
Pfizer Investigational Site
Gatineau, Quebec, J8Y 6S9, Canada
Pfizer Investigational Site
Granby, Quebec, J2G 8Z9, Canada
Pfizer Investigational Site
Longueuil, Quebec, J4N 1E1, Canada
Pfizer Investigational Site
Montreal, Quebec, H1T 1C8, Canada
Pfizer Investigational Site
Montreal, Quebec, H3T 1E2, Canada
Pfizer Investigational Site
Pointe-Claire, Quebec, H9R 4S3, Canada
Pfizer Investigational Site
Québec, Quebec, G1J 1Z4, Canada
Pfizer Investigational Site
Québec, Quebec, G1J 1Z6, Canada
Pfizer Investigational Site
Québec, Quebec, G1S 2L6, Canada
Pfizer Investigational Site
Saint-JĂ©rĂ´me, Quebec, J7Z 5T3, Canada
Pfizer Investigational Site
Saint-Lambert, Quebec, J4P 2H4, Canada
Pfizer Investigational Site
Saint-Marc-des-Carrieres, Quebec, G0A 4B0, Canada
Pfizer Investigational Site
Sherbrooke, Quebec, J1H 1Z1, Canada
Pfizer Investigational Site
St-Georges Ouest, Quebec, G5Y 4W1, Canada
Pfizer Investigational Site
Ste-foy, Quebec, G1V 4G2, Canada
Pfizer Investigational Site
Regina, Saskatchewan, S4P 3X3, Canada
Pfizer Investigational Site
Rimouski, G5L 9A8, Canada
Pfizer Investigational Site
St-Gedeon Beauce, G0M 1T0, Canada
Pfizer Investigational Site
St. John's, A1A 2E2, Canada
Pfizer Investigational Site
St. John's, A1A 3R5, Canada
Pfizer Investigational Site
St. John's, A1B 3E4, Canada
Pfizer Investigational Site
Ayr, Ayrshire, KA7 1BG, United Kingdom
Pfizer Investigational Site
Sandy, Bedfordshire, SG19 3JR, United Kingdom
Pfizer Investigational Site
Peterborough, Cambs, PE7 3JL, United Kingdom
Pfizer Investigational Site
Thornhill, Cardiff, CF14 9BB, United Kingdom
Pfizer Investigational Site
Fowey, Cornwall, PL23 1DT, United Kingdom
Pfizer Investigational Site
Darlington, County Durham, DL16 6QA, United Kingdom
Pfizer Investigational Site
Darlington, County Durham, DL3 8SQ, United Kingdom
Pfizer Investigational Site
Paignton, Devon, TQ4 5LA, United Kingdom
Pfizer Investigational Site
Plymouth, Devon, PL5 3PY, United Kingdom
Pfizer Investigational Site
Bournemouth, Dorset, BH8 9EW, United Kingdom
Pfizer Investigational Site
Angus, Dundee, DD1 5LA, United Kingdom
Pfizer Investigational Site
Central Milton Keyne, England, MK9 2NR, United Kingdom
Pfizer Investigational Site
Lancaster, England, LA1 2LG, United Kingdom
Pfizer Investigational Site
Surrey, England, CR7 7JN, United Kingdom
Pfizer Investigational Site
Wishaw, Lanarkshire, England, ML2 7BG, United Kingdom
Pfizer Investigational Site
Leigh-on-Sea, Essex, SS9 2UW, United Kingdom
Pfizer Investigational Site
Newport, gWENT, NP18 1AZ, United Kingdom
Pfizer Investigational Site
Letchworth Garden City, Hertfordshire, SG6 4UB, United Kingdom
Pfizer Investigational Site
Canterbury, Kent, CT1 3NG, United Kingdom
Pfizer Investigational Site
Whitstable, Kent, CT5 1BZ, United Kingdom
Pfizer Investigational Site
Blackpool, Lancashire, FY4 3AD, United Kingdom
Pfizer Investigational Site
Spalding, Lincolnshire, PE11 2BH, United Kingdom
Pfizer Investigational Site
Bangor, Belfast, Northern Ireland, BT19 1PP, United Kingdom
Pfizer Investigational Site
Coatbridge, Scotland, ML5 3EE, United Kingdom
Pfizer Investigational Site
Glasgow, Scotland, G31 1QW, United Kingdom
Pfizer Investigational Site
Frome, Somerset, BA11 1EZ, United Kingdom
Pfizer Investigational Site
Stairfoot, Barnsley, South Yorkshire, S70 3RJ, United Kingdom
Pfizer Investigational Site
Weybridge, Surrey, KT15 2BH, United Kingdom
Pfizer Investigational Site
Leeds, West Yorkshire, LS12 1JE, United Kingdom
Pfizer Investigational Site
Sheffield, Yorkshire, S7 2DW, United Kingdom
Pfizer Investigational Site
Aberdeen, AB15 4ZT, United Kingdom
Pfizer Investigational Site
Berkshire, SL2 1HD, United Kingdom
Pfizer Investigational Site
Cambridge, CB5 8SP, United Kingdom
Pfizer Investigational Site
Canterbury, CT1 3HX, United Kingdom
Pfizer Investigational Site
Coventry, CV 8LA, United Kingdom
Pfizer Investigational Site
Coventry, CV7 8LA, United Kingdom
Pfizer Investigational Site
Dorking, RH4 2BG, United Kingdom
Pfizer Investigational Site
Dundee, DD2 5AD, United Kingdom
Pfizer Investigational Site
Glasgow, G20 7LR, United Kingdom
Pfizer Investigational Site
Glasgow, g31 1QS, United Kingdom
Pfizer Investigational Site
Glasgow, G32 7JG, United Kingdom
Pfizer Investigational Site
Hertfordshire, WD2 6EB, United Kingdom
Pfizer Investigational Site
Kent, TN10 3ET, United Kingdom
Pfizer Investigational Site
Leeds, LS25 1AN, United Kingdom
Pfizer Investigational Site
Newcastle upon Tyne, NE15 6TQ, United Kingdom
Pfizer Investigational Site
Newcastle upon Tyne, NE5 2UY, United Kingdom
Pfizer Investigational Site
Nottingham, NG4 3BP, United Kingdom
Pfizer Investigational Site
Rochdale, OL11 5AQ, United Kingdom
Pfizer Investigational Site
Shrewsbury, SY2 6DL, United Kingdom
Pfizer Investigational Site
Stourbridge, DY8 1AW, United Kingdom
Pfizer Investigational Site
Swanley, BR8 7AH, United Kingdom
Pfizer Investigational Site
Swindon, SN25 4YZ, United Kingdom
Pfizer Investigational Site
Related Publications (1)
Richard Hobbs FD, Gensini G, John Mancini GB, Manolis AJ, Bauer B, Genest J, Feldman RD, Harvey P, Jenssen TG, da Silva PM; JEWEL Study Group. International open-label studies to assess the efficacy and safety of single-pill amlodipine/atorvastatin in attaining blood pressure and lipid targets recommended by country-specific guidelines: the JEWEL programme. Eur J Cardiovasc Prev Rehabil. 2009 Aug;16(4):472-80. doi: 10.1097/HJR.0b013e32832b63f5.
PMID: 19407658DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Pfizer CT.gov Call Center
Pfizer
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- INDUSTRY
Study Record Dates
First Submitted
February 28, 2006
First Posted
May 29, 2006
Study Start
October 1, 2004
Study Completion
September 1, 2005
Last Updated
January 27, 2021
Record last verified: 2021-01