Rickettsial Genesis to Sarcoidosis in Denmark

NCT00326534 | Completed

• 2 other identifiers: KF 01 3037972006-41-6575
• Study Type: observational
• Target: 36
• Locations: 1 country
• Sites: 1

Brief Summary

One study has suggested a connection between an infection with Rickettsia species and sarcoidosis finding molecular evidence of rickettsial deoxyribonucleic acid (DNA) in two patients. Another study found no antibodies in twenty Swedish patients with sarcoidosis. This study will further enhance the subject by three different approaches in Danish patients. The purpose of this study is to find serological and molecular evidence of an infection with Rickettsia species in Danish patients with sarcoidosis.

Conditions

Sarcoidosis; Rickettsia Infections

Keywords

Sarcoidosis; Rickettsia; Serological reactions; Polymerase chain reaction

Study Arms (2)

Controls

Patients without sarcoidosis, but requiring a fiberoptic bronchoscopy

Sarcoidosis patients

Patients with newly diagnosed sarcoidosis

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients referred to fiberoptic bronchoscopy in the department either because of sarcoidosis, hemoptysis, chronic cough, or cancer suspicion

You may qualify if:

• Referred to fiberoptic bronchoscopy in the department either because of sarcoidosis, hemoptysis, chronic cough, or cancer suspicion

You may not qualify if:

• Pregnant patients
• Patients under the age of 18
• Patients without consent
• Patients with a registered wish of not having their samples used for research

Sponsors & Collaborators

• Statens Serum Institut: lead
• Bispebjerg Hospital: collaborator
• Civilingeniør Johs. E. Ormstrup og Hustru Grete Ormstrups Fond: collaborator

Study Sites (1)

Denmark

Copenhagen S, 2300, Denmark

Location

Related Publications (3)

• Planck A, Eklund A, Grunewald J, Vene S. No serological evidence of Rickettsia helvetica infection in Scandinavian sarcoidosis patients. Eur Respir J. 2004 Nov;24(5):811-3. doi: 10.1183/09031936.04.00014604.

  PMID: 15516677 BACKGROUND

• Nilsson K, Pahlson C, Lukinius A, Eriksson L, Nilsson L, Lindquist O. Presence of Rickettsia helvetica in granulomatous tissue from patients with sarcoidosis. J Infect Dis. 2002 Apr 15;185(8):1128-38. doi: 10.1086/339962. Epub 2002 Mar 21.

  PMID: 11930323 BACKGROUND

• Svendsen CB, Milman N, Hoier-Madsen M, Dziegiel MH, Krogfelt KA. Determination of rickettsial and antinuclear antibodies in Danish patients with sarcoidosis. Clin Respir J. 2008 Oct;2(4):202-7. doi: 10.1111/j.1752-699X.2008.00051.x.

  PMID: 20298335 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

Buffy coats, serum, bronchoalveolar lavage fluid and transbronchial biopsies

MeSH Terms

Conditions

Sarcoidosis; Rickettsia Infections

Condition Hierarchy (Ancestors)

Lymphoproliferative Disorders; Lymphatic Diseases; Hemic and Lymphatic Diseases; Hypersensitivity, Delayed; Hypersensitivity; Immune System Diseases; Rickettsiaceae Infections; Gram-Negative Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Infections; Vector Borne Diseases

Study Officials

• Claus B Svendsen, MD

  Statens Serum Institut

  PRINCIPAL INVESTIGATOR

• Nils Milman, MD

  Rigshospitalet, Denmark

  STUDY CHAIR

• Karen A Krogfelt, PhD

  Statens Serum Institut

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 15, 2006
• First Posted: May 17, 2006
• Study Start: September 1, 2006
• Primary Completion: January 1, 2009
• Study Completion: March 1, 2009
• Last Updated: March 9, 2009

Record last verified: 2009-03

Locations

DK (1)