NCT00322959

Brief Summary

Tai-Chi-Chuan (TCC), a branch of traditional Chinese martial arts, has been widely practiced since the 17th century. Recent studies have shown that TCC can improve cardiorespiratory function, muscle strength, humoral and cellular immunity, metabolic response and mental control. Cultured monocytes from blood or bone marrow can be triggered to differentiate to myeloid dendritic cells (DC). DCs are specialized leukocytes for presenting antigens to quiescent, naive, and memory T cells, and they play pivotal roles in the induction of cell-mediated as well as humoral immune responses in vivo. Mature DCs have a capacity for initiating immunity or tolerance, which depends on their activation state. In this study we will investigate the effect of TCC on DC differentiation in the peripheral blood obtained from the healthy donors who take part with and without TCC exercise. The distribution of various DC sub-populations (myeloid DC and plasmacytoid cell) will be analyzed by detecting surface marker expression.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Aug 2004

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2004

Completed
1.8 years until next milestone

First Submitted

Initial submission to the registry

May 5, 2006

Completed
3 days until next milestone

First Posted

Study publicly available on registry

May 8, 2006

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2006

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2006

Completed
Last Updated

September 22, 2008

Status Verified

September 1, 2008

Enrollment Period

2.3 years

First QC Date

May 5, 2006

Last Update Submit

September 19, 2008

Conditions

Immunity

Keywords

dendritic cellsTai-Chi-Chuan

Eligibility Criteria

Age25 Years - 65 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

TCC practitioner and Healthy subjects as controls

You may qualify if:

  • Yang TCC practitioner who keep practicing at least 3 times a week for more than 3 years
  • Healthy subjects as controls

You may not qualify if:

  • Who have a history of significant cardiovascular, pulmonary, and musculoskeletal diseases

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Medical Research, Mackay Memorial Hospital

Taipei, 104, Taiwan

Location

Related Publications (1)

  • Lee JJ, Liao HF, Yang YC, Liu CL, Chen YY, Lin CP, Chen YJ. Platonin modulates differentiation and maturation of human monocyte-derived dendritic cells. Int Immunopharmacol. 2006 Feb;6(2):287-93. doi: 10.1016/j.intimp.2005.08.016. Epub 2005 Sep 15.

    PMID: 16399634BACKGROUND

Study Officials

  • Yu-Jen Chen, MD, PhD

    Mackay Memorial Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER

Study Record Dates

First Submitted

May 5, 2006

First Posted

May 8, 2006

Study Start

August 1, 2004

Primary Completion

November 1, 2006

Study Completion

November 1, 2006

Last Updated

September 22, 2008

Record last verified: 2008-09

Locations

TW(1)