Evaluation of Whether Functional Strength Training Can Enhance Recovery of Mobility After Stroke

NCT00322192 | Completed Phase 2

• 1 other identifier: Health Foundation 224/1960
• Study Type: interventional
• Target: 300
• Locations: 1 country
• Sites: 4

Brief Summary

The purpose of this study is to test the hypothesis that adding functional strength training to UK conventional therapy improves muscle function and walking than either UK conventional therapy alone or increased intensity of UK conventional therapy

Conditions

Stroke

Keywords

Stroke rehabilitation; Physical Therapy

Outcome Measures

Primary Outcomes (2)

• Maximum torque around the knee joint

• gait velocity

Secondary Outcomes (7)

• Modified Rivermead Mobility Index

• Lower limb kinematics during standing up

• Lower limb kinematics during sitting down

• Lower limb kinematics during walking

• timing and pattern of muscle activation during functional activity

Interventions

Conventional UK Physical therapy BEHAVIORAL

Increased intensity of UK conventional physical therapy BEHAVIORAL

UK conventional physical therapy plus functional strength training BEHAVIORAL

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjects in this study will:
• be aged over 50 years.
• be between one week and three months after stroke when recruited to the study;
• have been independently mobile indoors, with or without aids, before the stroke;
• have some voluntary movement in the paretic lower limb i.e. score above 28/100 on the lower limb section of the Motricity Index43;
• demonstrate adequate orientation and communication (be able to complete a one-stage command using the non-paretic upper limb e.g. point at the ceiling).
• In addition those who agree to participate in TMS measurement will have no contraindications to TMS.

Sponsors & Collaborators

• St George's, University of London: lead
• The Health Foundation: collaborator

Study Sites (4)

St George's Hospital NHS Trust

London, London, SW17 0RE, United Kingdom

Location

Epsom and St Helier NHS Trust

Carshalton, Surrey, SM5 1AA, United Kingdom

Location

Ashford and St Peter's Hospitals NHS Trust

Chertsey, Surrey, KT16 0PZ, United Kingdom

Location

Mayday University Hospital NHS Trust

Thornton Heath, Surrey, CR7 7YE, United Kingdom

Location

Related Publications (1)

• Kerr A, Clark A, Cooke EV, Rowe P, Pomeroy VM. Functional strength training and movement performance therapy produce analogous improvement in sit-to-stand early after stroke: early-phase randomised controlled trial. Physiotherapy. 2017 Sep;103(3):259-265. doi: 10.1016/j.physio.2015.12.006. Epub 2016 Feb 11.

  PMID: 27107979 DERIVED

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Valerie M Pomeroy, PhD

  St George's University London, UK

  STUDY CHAIR

• Emma V Cooke, MSc

  St George's University London, UK

  PRINCIPAL INVESTIGATOR

• Raymond C Tallis, FMedSci

  University of Manchester

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: SINGLE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: May 4, 2006
• First Posted: May 5, 2006
• Study Start: January 1, 2004
• Study Completion: December 1, 2006
• Last Updated: June 10, 2015

Record last verified: 2006-05

Locations

GB (4)