NCT00320125

Brief Summary

The purpose of the study is to evaluate the effects of different dietary calcium have on the pregnant teen mother and her newborn. We hypothesize that the higher calcium intake during pregnancy will result in higher bone mass in the newborn.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
72

participants targeted

Target at below P25 for phase_3 pregnancy

Timeline
Completed

Started Mar 2002

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2002

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2004

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2004

Completed
1.9 years until next milestone

First Submitted

Initial submission to the registry

April 28, 2006

Completed
5 days until next milestone

First Posted

Study publicly available on registry

May 3, 2006

Completed
Last Updated

May 5, 2015

Status Verified

October 1, 2008

Enrollment Period

2.3 years

First QC Date

April 28, 2006

Last Update Submit

May 1, 2015

Conditions

Keywords

DairyCalciumPregnancyFetusBone mineralization

Outcome Measures

Primary Outcomes (2)

  • Newborn bone mass

  • Maternal dietary intakes

Secondary Outcomes (3)

  • Newborn body weight

  • Maternal blood pressure

  • Newborn blood for calcium, phosphate, vitamin D

Study Arms (3)

1

NO INTERVENTION

Usual diet

2

ACTIVE COMPARATOR

Orange juice fortified with calcium

Dietary Supplement: Orange juice plus calcium

3

ACTIVE COMPARATOR

Dairy products

Dietary Supplement: Dairy products

Interventions

Orange juice plus calciumDIETARY_SUPPLEMENT

\> 1,200mg Ca (four glasses of orange juice plus calcium)per day

2
Dairy productsDIETARY_SUPPLEMENT

\> 1,200mg Ca (by consuming milk, yogurt, and cheese)

3

Eligibility Criteria

Age15 Years - 18 Years
Sexfemale
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Pregnant mothers aged 15 to 18 years, term gestation

You may not qualify if:

  • Chronic disease such as hypertension, diabetes, medications that will affect calcium metabolism

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital

Salt Lake City, Utah, 84132, United States

Location

Related Publications (5)

  • Thomas M, Weisman SM. Calcium supplementation during pregnancy and lactation: effects on the mother and the fetus. Am J Obstet Gynecol. 2006 Apr;194(4):937-45. doi: 10.1016/j.ajog.2005.05.032.

  • Koo WW, Walters JC, Esterlitz J, Levine RJ, Bush AJ, Sibai B. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol. 1999 Oct;94(4):577-82. doi: 10.1016/s0029-7844(99)00371-3.

  • Merrilees MJ, Smart EJ, Gilchrist NL, Frampton C, Turner JG, Hooke E, March RL, Maguire P. Effects of diary food supplements on bone mineral density in teenage girls. Eur J Nutr. 2000 Dec;39(6):256-62. doi: 10.1007/s003940070004.

  • Chan GM, McElligott K, McNaught T, Gill G. Effects of dietary calcium intervention on adolescent mothers and newborns: A randomized controlled trial. Obstet Gynecol. 2006 Sep;108(3 Pt 1):565-71. doi: 10.1097/01.AOG.0000231721.42823.9e.

  • Kongwattanakul K, Duangkum C, Ngamjarus C, Lumbiganon P, Cuthbert A, Weeks J, Sothornwit J. Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes. Cochrane Database Syst Rev. 2024 Nov 19;11(11):CD007079. doi: 10.1002/14651858.CD007079.pub4.

Related Links

MeSH Terms

Interventions

CalciumDairy Products

Intervention Hierarchy (Ancestors)

Metals, Alkaline EarthElementsInorganic ChemicalsMetalsBlood Coagulation FactorsBiological FactorsFoodDiet, Food, and NutritionPhysiological PhenomenaFood and Beverages

Study Officials

  • Gary M Chan, MD

    University of Utah

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

April 28, 2006

First Posted

May 3, 2006

Study Start

March 1, 2002

Primary Completion

June 1, 2004

Study Completion

June 1, 2004

Last Updated

May 5, 2015

Record last verified: 2008-10

Locations