The Effect of Acupuncture on Infertility With In-Vitro Fertilization (IVF) Patients
Acupuncture for Infertility Patients: The Effect on IVF
1 other identifier
interventional
60
1 country
2
Brief Summary
Infertility is a common problem with increased incidence. In-vitro fertilization (IVF) is by far the most commonly used treatment. The success rate of IVF is still low. This study examines the effect of acupuncture on IVF pregnancy rate, as well as possible mechanisms. It is hypothesized that acupuncture can significantly increase the IVF pregnancy rate.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_1
Started Oct 2005
Longer than P75 for phase_1
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2005
CompletedFirst Submitted
Initial submission to the registry
April 20, 2006
CompletedFirst Posted
Study publicly available on registry
April 24, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2009
CompletedSeptember 11, 2019
August 1, 2009
3.3 years
April 20, 2006
September 10, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Clinical pregnancy rate
6 to 8 weeks
Secondary Outcomes (4)
Miscarriage rate
one year
Take home baby rate
one year
B-endorphin levels
2 weeks
Stress measurement
4 weeks
Interventions
4 acupuncture treatments will be conducted during the IVF cycle. The 1st one is at the beginning of egg stimulation, the 2nd one is before the egg retrieval, the 3rd and 4th one are before and after the embryo transfer
Eligibility Criteria
You may qualify if:
- Patient is undergoing in-vitro fertilization protocol (both IVF and intracytoplasmic sperm injection - ICSI)
- Patient is acupuncture naïve.
- Patient has basal serum follicle-stimulating hormone (FSH) \< 10
- Patient has given informed consent to participate in study
You may not qualify if:
- Patient has had acupuncture performed previously or currently
- Patient has basal serum FSH of 10 or more
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Reproductive Endocrinology and Infertility, Dept. of OB/GYN
Baltimore, Maryland, 21201, United States
The GBMC Fertility Center
Baltimore, Maryland, 21204, United States
Related Publications (1)
Paulus WE, Zhang M, Strehler E, El-Danasouri I, Sterzik K. Influence of acupuncture on the pregnancy rate in patients who undergo assisted reproduction therapy. Fertil Steril. 2002 Apr;77(4):721-4. doi: 10.1016/s0015-0282(01)03273-3.
PMID: 11937123BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Grant Zhang, Ph.D.
Center For Integrative Medicine, University of Maryland
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- NIH
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
April 20, 2006
First Posted
April 24, 2006
Study Start
October 1, 2005
Primary Completion
February 1, 2009
Study Completion
November 1, 2009
Last Updated
September 11, 2019
Record last verified: 2009-08