A Phase I Study of the Oral Platinum Agent Satraplatin in Combination With Weekly Docetaxel

NCT00313456 | Terminated Phase 1

• 1 other identifier: SAT1-05-09
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

This is a single-center, open-label (sequential-group dose-escalation dose-finding) phase I study of satraplatin and docetaxel in patients who have received prior chemotherapy regimens. Once the MTD is determined, an additional 6 patients, all with chemotherapy-naïve HRPC, will be enrolled. Once a recommended dose(s) (RD(s)) for phase 2 studies has/have been determined, 6 additional patients with chemotherapy-naïve HRPC will be enrolled at the RD to further evaluate safety and efficacy.

Conditions

Tumors; Prostate Cancer

Outcome Measures

Primary Outcomes (1)

• To assess the maximum tolerated dose (MTD) of satraplatin administered every 4 weeks in combination with docetaxel administered weekly (3 of 4 weeks)

  30 days

Secondary Outcomes (2)

• To assess safety and tolerability (as per NCI-CTCAE version 3.0)

  30 days

• To assess preliminary antitumor activity

  6 months

Interventions

Satraplatin DRUG

Satraplatin is an oral platinum analogue that has shown promising activity in multiple tumor settings. Satraplatin (40 to 80 mg/m2/day) will be administered orally on days 1 to 5 of a 21 day cycle.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Histologically proven advanced solid tumors.
• prior chemotherapy regimens.
• Age greater than or equal to 18 years.
• Eastern Cooperative Oncology Group performance status 0-1.
• Life expectancy greater than 3 months.
• At least 4 weeks between prior surgery or radiotherapy and enrollment.
• Adequate organ function as defined by the following criteria (must be obtained within 1 week of the first day of treatment):
• Absolute neutrophil count ≥ 1500/µL. Hemoglobin ≥ 10.0 g/dl. Platelets ≥ 100,000/µL. Serum creatinine ≤ 1.5 upper limit of normal (ULN). Serum bilirubin ≤ ULN. AST/ALT ≤ 1.5 x the ULN.
• Patients must be able to swallow capsules.
• Patients must give written informed consent before study participation.
• No history of another cancer within the past 5 years (except basal or squamous cell carcinoma of the skin).
• No brain or leptomeningeal metastases.
• Female patients must not be pregnant or lactating and must be willing to practice contraception. Males must agree to contraceptive practices.
• For HRPC cohort
• Patient must continue to be administered an LHRH agonist if they were receiving it at the time of screening for entry onto this protocol. Patients who have undergone bilateral orchiectomy do not need to be on LHRH agonists.

You may not qualify if:

• Patients who are unwilling to use contraception.
• Patients with a history of major gastrointestinal surgery.
• Pre-existing peripheral neuropathy \> grade 1.
• Pre-existing edema \> grade 1.
• Patients with hearing loss or tinnitus \> grade 2.
• Prior RT to \>25% of the bone marrow.
• Concomitant use of medications that inhibit cytochrome P450 3A4 (including aprepitant).
• Other concurrent chemotherapy, immunotherapy, radiotherapy, or any ancillary therapy considered investigational (utilized for non-FDA - approved indications and in the context of a research investigation).
• Patients who have not recovered (≥ grade 1) from the following toxicities of previous regimens before enrollment:
• hematologic toxicities (parameters defined in protocol
• fatigue
• mucositis
• nausea/vomiting/diarrhea.
• Uncontrolled intercurrent illness including, but not limited to, ongoing active infection, uncontrolled congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness that would limit compliance with study requirements.
• History of HIV or AIDS related illness.

Sponsors & Collaborators

• Agennix: lead

Study Sites (1)

Sarah Cannon Research Institute

Nashville, Tennessee, United States

Location

MeSH Terms

Conditions

Neoplasms; Prostatic Neoplasms

Interventions

satraplatin

Condition Hierarchy (Ancestors)

Genital Neoplasms, Male; Urogenital Neoplasms; Neoplasms by Site; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Prostatic Diseases; Male Urogenital Diseases

Study Officials

• Michael Petrone, MD

  GPC Biotech Inc.

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 10, 2006
• First Posted: April 12, 2006
• Study Start: March 1, 2006
• Primary Completion: March 1, 2009
• Study Completion: March 1, 2009
• Last Updated: May 10, 2012

Record last verified: 2012-05

Locations

US (1)