Aminophylline in Bradyasystolic Cardiac Arrest
1 other identifier
interventional
966
1 country
1
Brief Summary
The purpose of this study is to evaluate the effect of aminophylline in patients with out-of-hospital bradyasystolic cardiac arrest.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_2
Started Jan 2001
Typical duration for phase_2
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2001
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2004
CompletedFirst Submitted
Initial submission to the registry
April 5, 2006
CompletedFirst Posted
Study publicly available on registry
April 7, 2006
CompletedJuly 27, 2006
September 1, 2003
April 5, 2006
July 26, 2006
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
The return of spontaneous circulation (ROSC), defined as the development of a palpable pulse of any duration.
Secondary Outcomes (10)
Maximum duration of ROSC (the duration of the longest episode of sustained pulse return)
ROSC duration by survival analysis
Survival to hospital admission
Survival to hospital discharge
Length of hospital stay
- +5 more secondary outcomes
Interventions
Eligibility Criteria
You may qualify if:
- Cardiac arrest
- Bradyasystole either as the presenting rhythm or as a rhythm developing during the course of the resuscitation
- Endotracheally intubated and ventilated with 100% oxygen
- Intravenous (IV) access established
- Bradyasystolic without palpable pulses after 1 mg of epinephrine and 3 mg of atropine.
You may not qualify if:
- A do-not-resuscitate directive
- Pregnancy
- Evidence of hemorrhage, trauma or hypothermia as a cause of the cardiac arrest
- Renal dialysis
- Theophylline hypersensitivity
- Patients taking an oral theophylline product
- Resuscitations directed by a paramedic student under practicum supervision
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Vancouver General Hospitallead
- Heart and Stroke Foundation of Canadacollaborator
- Vancouver Coastal Health Research Institutecollaborator
Study Sites (1)
Vancouver General Hospital
Vancouver, British Columbia, V5Z 1M9, Canada
Related Publications (1)
Abu-Laban RB, McIntyre CM, Christenson JM, van Beek CA, Innes GD, O'Brien RK, Wanger KP, McKnight RD, Gin KG, Zed PJ, Watts J, Puskaric J, MacPhail IA, Berringer RG, Milner RA. Aminophylline in bradyasystolic cardiac arrest: a randomised placebo-controlled trial. Lancet. 2006 May 13;367(9522):1577-84. doi: 10.1016/S0140-6736(06)68694-7.
PMID: 16698410RESULT
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Riyad B Abu Laban, MD, MHSc
Department of Emergency Medicine, Vancouver General Hospital
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
April 5, 2006
First Posted
April 7, 2006
Study Start
January 1, 2001
Study Completion
July 1, 2004
Last Updated
July 27, 2006
Record last verified: 2003-09