Advancement of Psychophysics of Pain Modulation From Lab to Clinic: Constructing Susceptibility Profile for Appearance of Postoperative Neuropathic Pain

NCT00305136 | Completed

• 2 other identifiers: Thoracotomy02CTILISF
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Recent advances in the field of pain psychophysics that have enhanced the understanding of pain processing by the nervous system seem to characterize the individual pattern of pain processing, thereby enabling the prediction of a person's susceptibility to develop chronic pain consequent to surgery. In this project, the researchers propose to apply a wide array of advanced testing methods in order to prospectively assess the pain modulation pattern of pain free patients about to undergo an elective thoracotomy. Since about half of post-thoracotomy patients suffer from chronic neuropathic postoperative pain, the researchers expect to identify which tests predict a risk for this pain and the relative power of the relevant tests in this prediction, and to construct a short and applicable tool, the 'pain susceptibility profile', that will reliably predict the risk for the development of pain. The expected results of this project will serve the field of pain prevention by identifying patients at risk and tailoring interventions to reduce the risk of chronic pain.

Conditions

Pain, Postoperative

Keywords

thoracotomy; post-operative pain; chronic pain; endogenous analgesia; temporal summation; central sensitization; prediction; Patients Who Should Undergo Thoracotomy

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Inclusion Criteria: * Pain free patients to undergo major thoracic operation with both malignant and non-malignant diseases. Exclusion Criteria: * Psychiatric or cognitive dysfunction precluding use of psychophysics * Existing thoracic pain * Patients who cannot communicate in Hebrew

You may qualify if:

• Pain free patients to undergo major thoracic operation with both malignant and non-malignant diseases.

You may not qualify if:

• Psychiatric or cognitive dysfunction precluding use of psychophysics
• Existing thoracic pain
• Patients who cannot communicate in Hebrew

Sponsors & Collaborators

• Rambam Health Care Campus: lead
• Israel Scientific Foundation: collaborator

Study Sites (1)

Rambam Medical Center

Haifa, 31096, Israel

Location

MeSH Terms

Conditions

Pain, Postoperative; Chronic Pain

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• David Yarnitsky, Professor

  Neurology Department Chairman, Rambam Medical Center, Haifa, Israel

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Neurology department

Study Record Dates

• First Submitted: March 19, 2006
• First Posted: March 21, 2006
• Study Start: December 1, 2005
• Primary Completion: January 1, 2010
• Study Completion: December 1, 2011
• Last Updated: October 11, 2017

Record last verified: 2017-10

Locations

IL (1)