NCT00304967

Brief Summary

This study will use a method called dynamic light scattering (DLS) to study the lens of the eye in young normal subjects. The DLS device uses a very dim laser light to study the lens of the eye. It detects proteins in the lens, identifying early changes that may make the device useful in future cataract studies. This study will use DLS to examine the characteristics of proteins in healthy young lenses that can be used for comparison with lenses in older people and people with cataracts. Normal volunteers aged 5 to 21 years may be eligible for this study. Participants undergo the following procedures: Medical history Eye examination with dilation to include:

  • Measurement of visual acuity
  • Examination of pupils and eye movements
  • Examination of the front of the eye (cornea, lens) with a slit lamp bio-microscope
  • Examination of retina with an ophthalmoscope (instrument with a strong light and magnifying lens)
  • Dynamic light scattering

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Mar 2006

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 15, 2006

Completed
3 days until next milestone

First Submitted

Initial submission to the registry

March 18, 2006

Completed
2 days until next milestone

First Posted

Study publicly available on registry

March 20, 2006

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2007

Completed
Last Updated

July 2, 2017

Status Verified

March 31, 2007

First QC Date

March 18, 2006

Last Update Submit

June 30, 2017

Conditions

Healthy

Keywords

CataractNormal LensesLens CrystallinesDynamic or Quasielastic Light Scattering (DLS)Eye ExaminationsHealthy VolunteerHVEye Examination

Eligibility Criteria

Age5 Years - 21 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • The study will enroll 30 normal control subjects, aged 5-21 years. Eligible participants must have normal clear lenses as determined by the eye examination.

You may not qualify if:

  • Individuals who cannot cooperate or keep still for the DLS measurements will be excluded.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (1)

  • Van Laethem M, Babusiaux B, Neetens A, Clauwaert J. Photon correlation spectroscopy of light scattered by eye lenses in in vivo conditions. Biophys J. 1991 Feb;59(2):433-44. doi: 10.1016/S0006-3495(91)82237-8.

    PMID: 2009358BACKGROUND

MeSH Terms

Conditions

Cataract

Condition Hierarchy (Ancestors)

Lens DiseasesEye Diseases

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

March 18, 2006

First Posted

March 20, 2006

Study Start

March 15, 2006

Study Completion

March 31, 2007

Last Updated

July 2, 2017

Record last verified: 2007-03-31

Locations

US(1)