Functional MR Urography
Interest of MR Urography in the Evaluation of Functional Consequences of Urinary Tract in Children and Adults
1 other identifier
interventional
550
1 country
16
Brief Summary
The objective of functional Uro MR is to add to an initial morphological phase, based on T2 and T1 weighted MR sequences, a sequential contrast-enhanced acquisition allowing to obtain functional semi-quantitative parameters from time-intensity curves from ROIs placed on the aorta, renal parenchyma and cavities. If the equivalence with the renal scintigraphy is demonstrated, it would be possible to have both the morphological and functional approach of an obstructed kidney in one MR examination, without exposure to diagnostic irradiation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_4
Started Mar 2006
16 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2006
CompletedFirst Submitted
Initial submission to the registry
March 10, 2006
CompletedFirst Posted
Study publicly available on registry
March 13, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2007
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2008
CompletedJuly 22, 2011
October 1, 2006
1.8 years
March 10, 2006
July 21, 2011
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Main medical criterion
percentage of relative renal function of the obstructed kidney
Main economical criterion
reduction of patient's management cost in the case of a suspicion of chronic or intermittent urinary obstruction
Secondary Outcomes (2)
acceptability of the method by patient
reliability of the functional indicators provided by the software programme
Interventions
undergoing both renal scintigraphy and MR within a month
Eligibility Criteria
You may qualify if:
- children (age \> 1 month) and adults chronic or intermittent urinary obstruction suspected by the demonstration of uni- or bilateral dilatation of pelvo-caliceal cavities by ultrasound or CT scan.
- undergoing both renal scintigraphy and MR within a month
You may not qualify if:
- acute urinary obstruction unilateral renal agenesia and ectopic kidney renal transplantation contra-indications to MR : pace-maker, claustrophobia contra-indications to the administration of Gadolinium chelates, including pregnancy, allergy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (16)
Chu Angers
Angers, 49033, France
Chu Bordeaux
Bordeaux, 33076, France
Chru Lille
Lille, 59037, France
Ap-Hm Marseille
Marseille, 13005, France
Fondation LENVAL
Nice, 06200, France
AP-HP Trousseau
Paris, 75571, France
AP-HP Saint Vincent de Paul
Paris, 75674, France
AP-HP Robert Debré
Paris, 75935, France
AP-HP Bicêtre
Paris, 94275, France
Chu Poitiers
Poitiers, 86021, France
Chu Reims
Reims, 51092, France
Chu Rennes
Rennes, 35033, France
Chu Rouen
Rouen, 76031, France
Chu Strasbourg
Strasbourg, 67091, France
Chu Tours
Tours, 37044, France
CHU NANCY Hôpital Brabois enfant
Vandœuvre-lès-Nancy, 54011, France
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Michel CLAUDON, PhD
Service de Radiologie
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- DIAGNOSTIC
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
March 10, 2006
First Posted
March 13, 2006
Study Start
March 1, 2006
Primary Completion
December 1, 2007
Study Completion
March 1, 2008
Last Updated
July 22, 2011
Record last verified: 2006-10