Pilot Study on Shear-induced Platelet Aggregation in Acute Coronary Syndromes
REACS
1 other identifier
observational
97
1 country
1
Brief Summary
The purpose of this study is to determine whether shear-induced platelet aggregation is able to discriminate first acute coronary syndrome (ACS) from recurrent ACS
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Jun 2005
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2005
CompletedFirst Submitted
Initial submission to the registry
March 2, 2006
CompletedFirst Posted
Study publicly available on registry
March 6, 2006
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2010
CompletedJuly 13, 2026
December 1, 2011
4.3 years
March 2, 2006
July 10, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Measurement of platelet aggregation induced by shear rates
Using rotational viscometer
Day 1, Month 3
Secondary Outcomes (5)
Measurement of platelet aggregation induced by ADP (Adenosine 5'-diphosphate)
Day 1, Month 3
Measurement of P-selectin membrane density
Day 1, Month 3
Measurement of activated alphaIlbbeta3 membrane density
Day 1, Month 3
Determination of the number of platelet-leucocyte aggregates in the circulating blood
Day 1, Month 3
Measuring Von Willebrand factor
Day 1, Month 3
Eligibility Criteria
patients admitted in the intensive care unit with acute coronary syndrome
You may qualify if:
- over 18 years old. informed consent signed. acute coronary syndrome not associated with co-morbidity as bleeding diathesis or myocardial infarction during the procedure.
- clinical symptoms in agreement with myocardial infarction during the preceding 24 hours.
- CK OR troponin elevation and one or more of the following criteria: ECG modifications transient ST elevation\>1 mm. new inversion of ST \<1 mm on 2 contiguous derivations.
You may not qualify if:
- Acute coronary syndrome with persistent ST elevation. Angioplasty in emergency before blood sampling. Inflammatory disease or cancer. Coagulation abnormalities. Antiphospholipid syndrome. Treatment by vitamin K antagonist. Severe disease with life expectancy lower than 2 years. One-year follow up impossible.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Bichat Hospital
Paris, 75018, France
Related Publications (1)
Ajzenberg N, Ducrocq G, Farnoud R, Huisse MG, Alavoine L, Duval X, Mentre F, Steg PG. Recurrent acute coronary syndromes are associated with increased shear induced platelet aggregation. A case-control study. Int J Cardiol. 2012 Mar 8;155(2):313-4. doi: 10.1016/j.ijcard.2011.12.005. Epub 2011 Dec 26. No abstract available.
PMID: 22204850RESULT
Biospecimen
serum, plasma, urines
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Philippe G Steg, Professor
APHP
- PRINCIPAL INVESTIGATOR
Nadine Ajzenberg, Dr
APHP, INSERM
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
March 2, 2006
First Posted
March 6, 2006
Study Start
June 1, 2005
Primary Completion
September 1, 2009
Study Completion
June 1, 2010
Last Updated
July 13, 2026
Record last verified: 2011-12