NCT00298740

Brief Summary

This research is being done to find out whether subjects previously treated with the implantable insulin pump (IIP) therapy, and now taking insulin by injection, will benefit from re-implantation of IIP. The investigators will see if IIP causes more stable control of blood sugar, with fewer highs and lows. People with type 1 diabetes previously implanted with the MiniMed Implantable Pump (MIP) model 2000 at Johns Hopkins may join this study.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
12

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Feb 2003

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2003

Completed
3.1 years until next milestone

First Submitted

Initial submission to the registry

March 1, 2006

Completed
2 days until next milestone

First Posted

Study publicly available on registry

March 3, 2006

Completed
3.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 24, 2009

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

September 24, 2009

Completed
8 years until next milestone

Results Posted

Study results publicly available

September 12, 2017

Completed
Last Updated

September 12, 2017

Status Verified

September 1, 2017

Enrollment Period

6.6 years

First QC Date

March 1, 2006

Results QC Date

August 10, 2017

Last Update Submit

September 8, 2017

Conditions

Outcome Measures

Primary Outcomes (1)

  • Glucose Control as Assessed by Mean Glucose Levels

    End of study, approximately 5 years

Study Arms (1)

Aventis U-400 Insulin

EXPERIMENTAL
Device: Aventis U-400 Insulin

Interventions

Aventis U-400 Insulin

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • People with type 1 diabetes previously implanted with the MiniMed Implantable Pump model 2000 at Johns Hopkins may join this study.

You may not qualify if:

  • Anyone not previously implanted with the MiniMed Implantable Pump model 2000 at Johns Hopkins.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Johns Hopkins University

Baltimore, Maryland, 21287, United States

Location

Related Publications (2)

  • Witkowski CJ, Saudek C. The implantable peritoneal pump--a patient's perspective. J Diabetes Sci Technol. 2008 Jul;2(4):703-6. doi: 10.1177/193229680800200423.

    PMID: 19885248BACKGROUND
  • Moore KB, Saudek CD, Greene A, Dackiw A. Implantable insulin pump therapy: an unusual presentation of a catheter-related complication. Diabetes Technol Ther. 2006 Jun;8(3):397-401. doi: 10.1089/dia.2006.8.397.

    PMID: 16800761BACKGROUND

MeSH Terms

Conditions

Diabetes Mellitus, Type 1

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesAutoimmune DiseasesImmune System Diseases

Results Point of Contact

Title
Johns Hopkins ClinicalTrials.gov Program
Organization
Johns Hopkins University

Study Officials

  • Christopher D Saudek, MD

    Johns Hopkins University

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 1, 2006

First Posted

March 3, 2006

Study Start

February 1, 2003

Primary Completion

September 24, 2009

Study Completion

September 24, 2009

Last Updated

September 12, 2017

Results First Posted

September 12, 2017

Record last verified: 2017-09

Locations