NCT00297505

Brief Summary

The purpose of this study is to compare the effects of citalopram versus placebo given in the context of contingency management for cocaine dependence.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
120

participants targeted

Target at P50-P75 for phase_2

Timeline
Completed

Started Apr 2001

Typical duration for phase_2

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2001

Completed
3.6 years until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2004

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

February 27, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

February 28, 2006

Completed
Last Updated

January 12, 2017

Status Verified

February 1, 2006

First QC Date

February 27, 2006

Last Update Submit

January 11, 2017

Conditions

Cocaine Dependence

Keywords

Cocaine; citalopram; impulsivity; serotonin

Outcome Measures

Primary Outcomes (1)

  • The presence of cocaine metabolites in urine weekly.

Secondary Outcomes (1)

  • Retention rate and cocaine cravings weekly.

Interventions

citalopramDRUG

Eligibility Criteria

Age18 Years - 50 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • male and female subjects age 18 to 50 who currently meet DSM-IV criteria for cocaine dependence.
  • female subjects: a negative pregnancy test

You may not qualify if:

  • current or past DSM-IV Axis I disorder other than substance abuse/dependence
  • any serious non-psychiatric medical illness requiring ongoing medical treatment
  • substance dependence other than cocaine within the last 3 months
  • negative urine drug screen for cocaine at time of testing
  • for female subjects: a positive pregnancy test

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Texas - Houston Health Science Center

Houston, Texas, 77030, United States

Location

Related Publications (1)

  • Moeller FG, Schmitz JM, Steinberg JL, Green CM, Reist C, Lai LY, Swann AC, Grabowski J. Citalopram combined with behavioral therapy reduces cocaine use: a double-blind, placebo-controlled trial. Am J Drug Alcohol Abuse. 2007;33(3):367-78. doi: 10.1080/00952990701313686.

    PMID: 17613964DERIVED

MeSH Terms

Conditions

Cocaine-Related DisordersImpulsive Behavior

Interventions

Citalopram

Condition Hierarchy (Ancestors)

Substance-Related DisordersChemically-Induced DisordersMental DisordersBehavior

Intervention Hierarchy (Ancestors)

PropylaminesAminesOrganic ChemicalsNitrilesBenzofuransHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-RingHeterocyclic Compounds

Study Officials

  • Frederick G Moeller, M.D.

    The University of Texas Health Science Center, Houston

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
NIH

Study Record Dates

First Submitted

February 27, 2006

First Posted

February 28, 2006

Study Start

April 1, 2001

Study Completion

November 1, 2004

Last Updated

January 12, 2017

Record last verified: 2006-02

Locations

US(1)