Conformation of Beta Human Chorionic Gonadotropin During Chemotherapy for Choriocarcinoma

NCT00294177 | Unknown

• 2 other identifiers: 9561702010Taiwan NSC 94WFA0101857
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Gestational trophoblastic disease comprises a spectrum of diseases with different propensity for local invasion and metastasis, that is, partial and complete hydatidiform mole, choriocarcinoma, and placental site trophoblastic tumor.All trophoblastic tumors produce hCG, and monitoring of therapy is largely based on the determination of hCG in serum. The conformational change of tumor markers during antineoplastic chemotherapy for cancer and its clinical meaning has only been rarely studied. In this study, we will try to understand the conformational change of the tumor marker (hCG) during chemotherapy.

Conditions

Trophoblastic Neoplasms; Choriocarcinoma

Keywords

Trophoblastic Neoplasms; Chorionic Gonadotropin; Molecular Conformation

Interventions

atomic force microscopy DEVICE

dual polarisation interferometry DEVICE

Eligibility Criteria

• Age: 0 Years+
• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Clinical diagnosis of trophoblastic neoplasms
• Willing to be collected for the urine and 2 ml blood samples

You may not qualify if:

• Unwilling to be collected for the collect urine or 2ml blood sample

Sponsors & Collaborators

• National Taiwan University Hospital: lead
• National Science and Technology Council, Taiwan: collaborator

Study Sites (1)

National Taiwan University Hospital Department of Obstetrics and Gynecology

Taipei, Taipei, 100, Taiwan

Location

Related Publications (3)

• Birken S, Armstrong EG, Kolks MA, Cole LA, Agosto GM, Krichevsky A, Vaitukaitis JL, Canfield RE. Structure of the human chorionic gonadotropin beta-subunit fragment from pregnancy urine. Endocrinology. 1988 Jul;123(1):572-83. doi: 10.1210/endo-123-1-572.

  PMID: 2454811 BACKGROUND

• Swann MJ, Peel LL, Carrington S, Freeman NJ. Dual-polarization interferometry: an analytical technique to measure changes in protein structure in real time, to determine the stoichiometry of binding events, and to differentiate between specific and nonspecific interactions. Anal Biochem. 2004 Jun 15;329(2):190-8. doi: 10.1016/j.ab.2004.02.019.

  PMID: 15158477 BACKGROUND

• Czajkowsky DM, Hotze EM, Shao Z, Tweten RK. Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membrane. EMBO J. 2004 Aug 18;23(16):3206-15. doi: 10.1038/sj.emboj.7600350. Epub 2004 Aug 5.

  PMID: 15297878 BACKGROUND

Related Links

• library of National taiwan University Hospital

MeSH Terms

Conditions

Trophoblastic Neoplasms; Choriocarcinoma

Interventions

Microscopy, Atomic Force

Condition Hierarchy (Ancestors)

Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Pregnancy Complications, Neoplastic; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial

Intervention Hierarchy (Ancestors)

Microscopy, Scanning Probe; Microscopy; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Study Officials

• Ruey-Jien Chen

  Department or Obstetrics and Gynecology, National Taiwan university Hospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ruey-Jien Chen, MD, PhD

CONTACT

886-2-23123456; rjchen@ha.mc.ntu.edu.tw

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: OTHER
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 17, 2006
• First Posted: February 20, 2006
• Study Start: August 1, 2006
• Study Completion: July 1, 2008
• Last Updated: February 20, 2006

Record last verified: 2006-02

Locations

TW (1)