Measuring Electrical Resistance of Different Tissues on the Outer Surface of the Heart

NCT00291174 | Terminated

• 1 other identifier: 803272
• Study Type: observational
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

This is a research study to evaluate the electrical properties of heart tissue. The purpose of this study is to determine the impedance (electrical resistance) of different tissues on the outer surface of the heart. This may be important for distinguishing scarred heart muscle from fat that can be seen on the surface of the heart. This information may eventually be utilized in patients that undergo a procedure (called catheter ablation) for the treatment of life-threatening heart rhythms. Investigators expect a detectable difference between the impedance of normal and infarcted myocardium (approximately 50 ohms).

Conditions

Cardiomyopathies; Ventricular Dysfunction; Myocardial Infarction; Arrhythmia

Keywords

Ventricular Arrhythmia; Myocardial Infarction; Ventricular Dysfunction; Coronary Artery Disease; Structural Heart Disease; Arrhythmia; Cardiomyopathies

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients undergoing elective cardiac surgery for coronary artery disease

You may qualify if:

• All adult patients undergoing elective cardiac surgery for coronary artery disease (with or without normal heart function) or valvular disease (with normal heart function) at the Hospital of the University of Pennsylvania under the direction of Y. Joseph Woo MD will be eligible.

You may not qualify if:

• Patients undergoing emergent surgery and patients with idiopathic cardiomyopathy, infiltrative cardiomyopathies and hypertrophic cardiomyopathies will be excluded.

Sponsors & Collaborators

• University of Pennsylvania: lead
• Biosense Webster, Inc.: collaborator

Study Sites (1)

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

Related Publications (17)

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  PMID: 3689045 BACKGROUND

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  PMID: 3621491 BACKGROUND

• Salazar Y, Bragos R, Casas O, Cinca J, Rosell J. Transmural versus nontransmural in situ electrical impedance spectrum for healthy, ischemic, and healed myocardium. IEEE Trans Biomed Eng. 2004 Aug;51(8):1421-7. doi: 10.1109/TBME.2004.828030.

  PMID: 15311828 BACKGROUND

• Salazar Y, Cinca J, Rosell-Ferrer J. Effect of electrode locations and respiration in the characterization of myocardial tissue using a transcatheter impedance method. Physiol Meas. 2004 Oct;25(5):1095-103. doi: 10.1088/0967-3334/25/5/001.

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• Schwartzman D, Chang I, Michele JJ, Mirotznik MS, Foster KR. Electrical impedance properties of normal and chronically infarcted left ventricular myocardium. J Interv Card Electrophysiol. 1999 Oct;3(3):213-24. doi: 10.1023/a:1009887306055.

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• Wolf T, Gepstein L, Hayam G, Zaretzky A, Shofty R, Kirshenbaum D, Uretzky G, Oron U, Ben-Haim SA. Three-dimensional endocardial impedance mapping: a new approach for myocardial infarction assessment. Am J Physiol Heart Circ Physiol. 2001 Jan;280(1):H179-88. doi: 10.1152/ajpheart.2001.280.1.H179.

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  PMID: 15798226 BACKGROUND

MeSH Terms

Conditions

Cardiomyopathies; Ventricular Dysfunction; Myocardial Infarction; Arrhythmias, Cardiac; Coronary Artery Disease

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Myocardial Ischemia; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis; Coronary Disease; Arteriosclerosis; Arterial Occlusive Diseases

Study Officials

• David J. Callans, MD

  University of Pennsylvania, Dept of Medicine, Cardiology Division

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 10, 2006
• First Posted: February 13, 2006
• Study Start: April 1, 2006
• Primary Completion: July 1, 2006
• Study Completion: January 1, 2008
• Last Updated: August 16, 2016

Record last verified: 2016-08

Locations

US (1)