NCT00290264

Brief Summary

The primary objective is to compare the efficacy of Symbicort Single inhaler Therapy with treatment according to conventional best practice in adolescent and adult patients with persistent asthma.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,000

participants targeted

Target at P75+ for phase_3 asthma

Timeline
Completed

Started Dec 2004

Geographic Reach
2 countries

209 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2004

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

February 9, 2006

Completed
4 days until next milestone

First Posted

Study publicly available on registry

February 13, 2006

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2006

Completed
Last Updated

January 24, 2011

Status Verified

January 1, 2011

First QC Date

February 9, 2006

Last Update Submit

January 21, 2011

Conditions

Outcome Measures

Primary Outcomes (1)

  • Time to first severe asthma exacerbation

Secondary Outcomes (4)

  • Number of severe asthma exacerbations

  • Mean use of as-needed medication

  • Prescribed asthma medication

  • Peak Expiratory Flow (PEF)

Interventions

Also known as: Symbicort

Eligibility Criteria

Age12 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Minimum of 3 months documented history of asthma, diagnosed according to the American Thoracic Society (ATS) definition.
  • Prescribed inhaled GCS at a dose of ≥320 µg/day and within the approved label for the relevant drug during the last 3 months prior to Visit 1.

You may not qualify if:

  • Use of any b-blocking agent, including eye-drops.
  • Use of oral GCS as maintenance treatment.
  • Known or suspected hypersensitivity to study therapy or excipients.
  • A history of smoking ≥ 10 pack years (1 pack year = 1 pack (20 cigarettes) per day for one year or equivalent).

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (209)

Research Site

Aalst, Belgium

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Aartrijke, Belgium

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Alsemberg, Belgium

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Anderlecht, Belgium

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Angleur, Belgium

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Ans, Belgium

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Antwerp, Belgium

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Anzegem, Belgium

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Arlon, Belgium

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Asse, Belgium

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Aywaille, Belgium

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Balen, Belgium

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Barry, Belgium

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Bastogne, Belgium

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Battice, Belgium

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Bellaire, Belgium

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Berchem, Belgium

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Bertrix, Belgium

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Beyne-Heusay, Belgium

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Bilzen, Belgium

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Binche, Belgium

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Bois-de-Villers, Belgium

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Bornem, Belgium

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Bouillon, Belgium

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Boussu, Belgium

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Brasschaat, Belgium

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Bruges, Belgium

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Brussels, Belgium

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Burdinne, Belgium

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Casteau, Belgium

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Champion, Belgium

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Chapelle-lez-Herlaimont, Belgium

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Charleroi, Belgium

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Châtelet, Belgium

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Chênée, Belgium

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Corbion, Belgium

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Couillet, Belgium

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De Pinte, Belgium

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Dendermonde, Belgium

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Deurne, Belgium

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Diksmuide, Belgium

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Dinant, Belgium

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Dour, Belgium

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Durnal, Belgium

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Dworp, Belgium

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Ekeren, Belgium

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Elversele, Belgium

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Erembodegem, Belgium

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Erquelinnes, Belgium

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Escanaffles, Belgium

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Essen, Belgium

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Etterbeek, Belgium

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Evere, Belgium

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Evergem, Belgium

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Écaussinnes-d'Enghien, Belgium

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Fleurus, Belgium

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Frameries, Belgium

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Ganshoren, Belgium

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Geluwe, Belgium

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Genk, Belgium

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Geraardsbergen, Belgium

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Ghent, Belgium

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Gilly, Belgium

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Godinne, Belgium

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Gozée, Belgium

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Grand-Halleux, Belgium

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Graty, Belgium

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Grivegnée, Belgium

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Ham-sur-Heure, Belgium

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Hamme, Belgium

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Hannut, Belgium

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Harzé, Belgium

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Hasselt, Belgium

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Havinnes, Belgium

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Havré, Belgium

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Heist-op-den-Berg, Belgium

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Heppen, Belgium

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Herent, Belgium

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Herentals, Belgium

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Herk-de-Stad, Belgium

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HermalleSousArgenteau, Belgium

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Herstal, Belgium

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Hever, Belgium

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Hoeselt, Belgium

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Hooglede, Belgium

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Hornu, Belgium

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Houthalen-Helchteren, Belgium

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Huldenberg, Belgium

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Ieper, Belgium

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Ingelmunster, Belgium

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Izegem, Belgium

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Kalmthout, Belgium

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Kinrooi-Ophoven, Belgium

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Kobbegem, Belgium

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Koksijde, Belgium

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Kontich, Belgium

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Koolskamp, Belgium

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Kortrijk, Belgium

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Kraainem, Belgium

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Lauwe, Belgium

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Leignon, Belgium

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Leuven, Belgium

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Libin, Belgium

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Libramont-Chevigny, Belgium

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Lier, Belgium

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Liège, Belgium

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Lobbes, Belgium

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Lokeren, Belgium

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Lommel, Belgium

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Louveigné, Belgium

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Lustin, Belgium

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Maasmechelen, Belgium

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Malmedy, Belgium

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Manage, Belgium

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Marche-en-Famenne, Belgium

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Marchovelette, Belgium

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Massemen, Belgium

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Mechelen, Belgium

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Meix-devant-Virton, Belgium

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Menen, Belgium

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Merbes-le-Château, Belgium

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Merksem, Belgium

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Messancy, Belgium

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Mettet, Belgium

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Middelkerke, Belgium

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Moerkerke, Belgium

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Mol, Belgium

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Monceau-sur-Sambre, Belgium

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Mons, Belgium

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Mont-Gauthier, Belgium

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Mont-sur-Marchienne, Belgium

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Montegnée, Belgium

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Montigny-le-Tilleul, Belgium

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Moorsel, Belgium

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Mortier, Belgium

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Mouscron, Belgium

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Munkzwalm, Belgium

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Munsterbilzen, Belgium

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Musson, Belgium

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Namur, Belgium

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Natoye, Belgium

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Nieuwenrode, Belgium

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Nieuwkerke, Belgium

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Nivelles, Belgium

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Noorderwijk, Belgium

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Oelegem, Belgium

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Olen, Belgium

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Ostend, Belgium

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Ottignies, Belgium

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Oudenaarde, Belgium

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Paal-Beringen, Belgium

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Paliseul, Belgium

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Petit-Rechain, Belgium

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Poederlee, Belgium

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Pondrôme, Belgium

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Reet, Belgium

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Rijkevorsel, Belgium

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Roeselare, Belgium

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Ronquière, Belgium

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Rumbeke, Belgium

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Sankt Vith, Belgium

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Seraing, Belgium

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Sibret, Belgium

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Sint-Eloois-Winkel, Belgium

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Sint-Niklaas, Belgium

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Sint-Ulriks-Kapelle, Belgium

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Souvret, Belgium

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Steenokkerzeel, Belgium

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Stekene, Belgium

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Tavier, Belgium

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Temse, Belgium

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Terhagen, Belgium

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Theux, Belgium

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Thieusies, Belgium

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Thuin, Belgium

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Tielt, Belgium

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Tienen, Belgium

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Tilff, Belgium

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Tournai, Belgium

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Tremelo, Belgium

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Trois-Ponts, Belgium

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Turnhout, Belgium

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Uccle, Belgium

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Vedrin, Belgium

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Verviers, Belgium

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Villers-Poterie-Charleroi, Belgium

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Vilvoorde, Belgium

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Vissenaken, Belgium

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Vosselaar, Belgium

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Waregem, Belgium

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Waremme, Belgium

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Welkenraedt, Belgium

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Wellin, Belgium

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Westerlo, Belgium

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Wetteren, Belgium

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Wilrijk, Belgium

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Yvoir, Belgium

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Zeebrugge, Belgium

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Zele, Belgium

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Zemst, Belgium

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Zoersel, Belgium

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Zottegem, Belgium

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Zulte, Belgium

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Zwalm, Belgium

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Zwevegem, Belgium

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Esch-sur-Alzette, Luxembourg

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Luxembourg, Luxembourg

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Niedercorn, Luxembourg

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Warken, Luxembourg

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Related Publications (1)

  • Louis R, Joos G, Michils A, Vandenhoven G. A comparison of budesonide/formoterol maintenance and reliever therapy vs. conventional best practice in asthma management. Int J Clin Pract. 2009 Oct;63(10):1479-88. doi: 10.1111/j.1742-1241.2009.02185.x.

MeSH Terms

Conditions

Asthma

Interventions

Budesonide, Formoterol Fumarate Drug Combination

Condition Hierarchy (Ancestors)

Bronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveLung DiseasesRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivityImmune System Diseases

Intervention Hierarchy (Ancestors)

Formoterol FumarateEthanolaminesAmino AlcoholsAlcoholsOrganic ChemicalsAminesBudesonidePregnenedionesPregnenesPregnanesSteroidsFused-Ring CompoundsPolycyclic CompoundsDrug CombinationsPharmaceutical Preparations

Study Officials

  • AstraZeneca Belgium Medical Director, MD

    AstraZeneca

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

February 9, 2006

First Posted

February 13, 2006

Study Start

December 1, 2004

Study Completion

August 1, 2006

Last Updated

January 24, 2011

Record last verified: 2011-01

Locations