NCT00289588

Brief Summary

The main purpose of this study is to determine if applying mupirocin into soldiers noses who are colonized with methicillin-resistant Staphylococcus aureus (MRSA) will reduce infections in them and their cohort of fellow soldiers.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
3,000

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Jan 2005

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2005

Completed
11 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2005

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

February 9, 2006

Completed
1 day until next milestone

First Posted

Study publicly available on registry

February 10, 2006

Completed
Last Updated

February 16, 2006

Status Verified

December 1, 2005

First QC Date

February 9, 2006

Last Update Submit

February 13, 2006

Conditions

Community-Acquired MRSA InfectionsAbscessesCellulitisFolliculitis

Keywords

Methicillin-resistant Staphylococcus aureusStaphylococcus aureusMRSACA-MRSA

Outcome Measures

Primary Outcomes (1)

  • Soft tissue infections in subjects who received the study medication and soft tissue infections in the study cohorts.

Secondary Outcomes (1)

  • Changes in S. aureus carriage rates (including MRSA).

Interventions

Mupirocin (drug)DRUG

Eligibility Criteria

Age17 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Brooke Army Medical Center

Fort Sam Houston, Texas, 78234, United States

Location

Related Publications (1)

  • Ellis MW, Hospenthal DR, Dooley DP, Gray PJ, Murray CK. Natural history of community-acquired methicillin-resistant Staphylococcus aureus colonization and infection in soldiers. Clin Infect Dis. 2004 Oct 1;39(7):971-9. doi: 10.1086/423965. Epub 2004 Sep 2.

    PMID: 15472848BACKGROUND

MeSH Terms

Conditions

AbscessCellulitisFolliculitisStaphylococcal Infections

Interventions

MupirocinPharmaceutical Preparations

Condition Hierarchy (Ancestors)

SuppurationInfectionsInflammationPathologic ProcessesPathological Conditions, Signs and SymptomsSkin Diseases, InfectiousConnective Tissue DiseasesSkin and Connective Tissue DiseasesHair DiseasesSkin DiseasesGram-Positive Bacterial InfectionsBacterial InfectionsBacterial Infections and Mycoses

Intervention Hierarchy (Ancestors)

Epoxy CompoundsEthers, CyclicEthersOrganic ChemicalsPyransHeterocyclic Compounds, 1-RingHeterocyclic CompoundsFatty AcidsLipids

Study Officials

  • Michael W Ellis, MD

    Brooke Army Medical Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
FED

Study Record Dates

First Submitted

February 9, 2006

First Posted

February 10, 2006

Study Start

January 1, 2005

Study Completion

December 1, 2005

Last Updated

February 16, 2006

Record last verified: 2005-12

Locations

US(1)