NCT00280423

Brief Summary

This study is designed to find the optimal (best) doses of GW679769 that could be given daily to promote sleep onset and maintain sleep during the night without significant next-day thinking impairment and drowsiness in subjects with primary insomnia.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
342

participants targeted

Target at P75+ for phase_2

Timeline
Completed

Started Jan 2006

Shorter than P25 for phase_2

Geographic Reach
2 countries

71 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2006

Completed
18 days until next milestone

First Submitted

Initial submission to the registry

January 19, 2006

Completed
4 days until next milestone

First Posted

Study publicly available on registry

January 23, 2006

Completed
1 year until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2007

Completed
Last Updated

April 15, 2015

Status Verified

April 1, 2015

Enrollment Period

1.1 years

First QC Date

January 19, 2006

Last Update Submit

April 14, 2015

Conditions

Keywords

CognitionPolysomnographyPrimary InsomniaElectroencephalographySleep

Outcome Measures

Primary Outcomes (1)

  • Comparison of GW679769 and placebo on the time needed to fall asleep at bedtime on Nights 1/2, 13/14 and 27/28 of treatment, as assessed by electroencephalography and other physiological changes during sleep.

    28 Days

Secondary Outcomes (1)

  • Comparison of GW679769 and placebo effects on sleep maintenance and duration on Nights 1/2, 13/14 and 27/28 of treatment, as assessed by electroencephalography and subject diaries, and on next-day memory, alertness and physical coordination.

    28 Days

Interventions

Eligibility Criteria

Age18 Years - 64 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Difficulty going to sleep and/or staying asleep for at least the past 3 months.
  • Insomnia must result in significant distress or impairment in functioning at home, socially or at work.
  • Otherwise good health with no significant or unstable medical disorder including psychiatric, neurological, endocrine, heart, lung or gastrointestinal disorders, drug/alcohol abuse, cognitive impairment, cancer or chronic pain conditions such as arthritis.

You may not qualify if:

  • History of other sleep disorders such as sleep apnea or restless leg syndrome.
  • Regular sleep habits, including bedtime between 9 PM and midnight.
  • No nightshift/rotating shift work, frequent napping or planned travel across \>2 time zones.
  • Use of nicotine, caffeine and alcoholic products.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (71)

GSK Investigational Site

Birmingham, Alabama, 35213, United States

Location

GSK Investigational Site

Phoenix, Arizona, 85050, United States

Location

GSK Investigational Site

Tucson, Arizona, 85712, United States

Location

GSK Investigational Site

Little Rock, Arkansas, 72205, United States

Location

GSK Investigational Site

Burbank, California, 91506, United States

Location

GSK Investigational Site

Huntington Beach, California, 92648, United States

Location

GSK Investigational Site

Irvine, California, 92618, United States

Location

GSK Investigational Site

Los Angeles, California, 90048, United States

Location

GSK Investigational Site

National City, California, 91950, United States

Location

GSK Investigational Site

San Diego, California, 92121, United States

Location

GSK Investigational Site

San Diego, California, 92123, United States

Location

GSK Investigational Site

San Diego, California, 92161, United States

Location

GSK Investigational Site

San Francisco, California, 94105, United States

Location

GSK Investigational Site

Santa Rosa, California, 95405, United States

Location

GSK Investigational Site

Norwalk, Connecticut, 06850, United States

Location

GSK Investigational Site

DeLand, Florida, 32720, United States

Location

GSK Investigational Site

Delray Beach, Florida, 33484, United States

Location

GSK Investigational Site

Hallandale, Florida, 33009, United States

Location

GSK Investigational Site

Largo, Florida, 33773, United States

Location

GSK Investigational Site

Miami, Florida, 33143, United States

Location

GSK Investigational Site

Miami, Florida, 33173, United States

Location

GSK Investigational Site

Miami, Florida, 33176, United States

Location

GSK Investigational Site

Pembroke Pines, Florida, 33026, United States

Location

GSK Investigational Site

Atlanta, Georgia, 30328, United States

Location

GSK Investigational Site

Atlanta, Georgia, 30342, United States

Location

GSK Investigational Site

Gainesville, Georgia, 30501, United States

Location

GSK Investigational Site

Hinesville, Georgia, 31313, United States

Location

GSK Investigational Site

Macon, Georgia, 31201, United States

Location

GSK Investigational Site

Stockbridge, Georgia, 30281, United States

Location

GSK Investigational Site

Chicago, Illinois, 60611, United States

Location

GSK Investigational Site

Chicago, Illinois, 60612, United States

Location

GSK Investigational Site

Chicago, Illinois, 60634, United States

Location

GSK Investigational Site

Overland Park, Kansas, 66211, United States

Location

GSK Investigational Site

Crestview Hills, Kentucky, 41017, United States

Location

GSK Investigational Site

Rockville, Maryland, 20852, United States

Location

GSK Investigational Site

Newton, Massachusetts, 02459, United States

Location

GSK Investigational Site

Troy, Michigan, 48085, United States

Location

GSK Investigational Site

Hattiesburg, Mississippi, 39404, United States

Location

GSK Investigational Site

Las Vegas, Nevada, 89104, United States

Location

GSK Investigational Site

Clementon, New Jersey, 08021, United States

Location

GSK Investigational Site

West Seneca, New York, 14224, United States

Location

GSK Investigational Site

Durham, North Carolina, 27705, United States

Location

GSK Investigational Site

Salisbury, North Carolina, 28144, United States

Location

GSK Investigational Site

Winston-Salem, North Carolina, 27157, United States

Location

GSK Investigational Site

Beachwood, Ohio, 44122, United States

Location

GSK Investigational Site

Cincinnati, Ohio, 45227, United States

Location

GSK Investigational Site

Cincinnati, Ohio, 45246, United States

Location

GSK Investigational Site

Cleveland, Ohio, 44130, United States

Location

GSK Investigational Site

Gallipolis, Ohio, 45631, United States

Location

GSK Investigational Site

Oklahoma City, Oklahoma, 73112, United States

Location

GSK Investigational Site

Gresham, Oregon, 97020, United States

Location

GSK Investigational Site

Clarks Summit, Pennsylvania, 18411, United States

Location

GSK Investigational Site

Duncansville, Pennsylvania, 16635, United States

Location

GSK Investigational Site

Warwick, Rhode Island, 02886, United States

Location

GSK Investigational Site

Columbia, South Carolina, 29201, United States

Location

GSK Investigational Site

Austin, Texas, 78756, United States

Location

GSK Investigational Site

Bellaire, Texas, 77401, United States

Location

GSK Investigational Site

Dallas, Texas, 75251, United States

Location

GSK Investigational Site

Houston, Texas, 77030, United States

Location

GSK Investigational Site

Plano, Texas, 75093, United States

Location

GSK Investigational Site

Salt Lake City, Utah, 84107, United States

Location

GSK Investigational Site

Calgary, Alberta, T2X 2A8, Canada

Location

GSK Investigational Site

Mississauga, Ontario, L5B4M4, Canada

Location

GSK Investigational Site

Niagara Falls, Ontario, L2G 1J4, Canada

Location

GSK Investigational Site

Parrry Sound, Ontario, P2A 1T3, Canada

Location

GSK Investigational Site

Toronto, Ontario, M4P 1P2, Canada

Location

GSK Investigational Site

Toronto, Ontario, M5G 1E2, Canada

Location

GSK Investigational Site

Toronto, Ontario, M5T3A9, Canada

Location

GSK Investigational Site

Toronto, Ontario, M6J 3S3, Canada

Location

GSK Investigational Site

Montreal, Quebec, H4J 1C5, Canada

Location

GSK Investigational Site

Sainte-Foy, Quebec, G1V 4G5, Canada

Location

MeSH Terms

Conditions

Sleep Initiation and Maintenance Disorders

Interventions

casopitant

Condition Hierarchy (Ancestors)

Sleep Disorders, IntrinsicDyssomniasSleep Wake DisordersNervous System DiseasesMental Disorders

Study Officials

  • GSK Clinical Trials

    GlaxoSmithKline

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 19, 2006

First Posted

January 23, 2006

Study Start

January 1, 2006

Primary Completion

February 1, 2007

Study Completion

February 1, 2007

Last Updated

April 15, 2015

Record last verified: 2015-04

Locations