Implementation Strategies for a Simple Intervention to Reduce Longterm Benzodiazepine Use in Dutch Community Pharmacies
Implementation Strategies Aimed at a Simple Patient-directed Intervention to Reduce Long-term Use of Benzodiazepines in Dutch Community Pharmacies
1 other identifier
interventional
20,000
1 country
90
Brief Summary
The purpose of this study is to compare the effect of two implementation strategies for a simple patient-directed intervention to reduce long-term benzodiazepine use in Dutch community pharmacies.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Nov 2005
90 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
November 1, 2005
CompletedFirst Submitted
Initial submission to the registry
December 21, 2005
CompletedFirst Posted
Study publicly available on registry
December 22, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2006
CompletedAugust 18, 2009
August 1, 2009
1.1 years
December 21, 2005
August 17, 2009
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
percentage of general practitioners that reviewed and returned the list of longterm users.
percentage of letters sent by the pharmacists in the four months after receiving the manual.
percentage of long-term benzodiazepine users that managed to quit or significantly reduce their use in months 0-3, 4-6 and 10-12 after receiving the letter.
Secondary Outcomes (1)
evaluation of the implementation strategies
Interventions
Eligibility Criteria
You may qualify if:
- benzodiazepine use for more than 3 months in the last 12 months AND for more than 60 days in the last 2 months
You may not qualify if:
- treatment by psychiatrist, treatment of alcohol- or drug misuse, psychotic episodes in history, epilepsy, terminal disease, not mastering the Dutch language, individual criteria used by the family practitioner
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Radboud University Medical Centerlead
- Zorgverzekeraar CZcollaborator
- Scientific Institute for Dutch Pharmacists, The Netherlandscollaborator
Study Sites (90)
Apotheek Schellekens
's-Hertogenbosch, 5212 NC, Netherlands
Apotheek Cleij
's-Hertogenbosch, 5213 VG, Netherlands
Apotheek Empel
's-Hertogenbosch, 5236 AC, Netherlands
Apotheek Asten
Asten, 5721 EZ, Netherlands
Apotheek Bakel-Milheeze
Bakel, 5761 BN, Netherlands
Kring-apotheek Bergeyk
Bergeijk, 5571 HE, Netherlands
Apotheek Berlicum
Berlicum, 5258 AW, Netherlands
Lloyds Apotheek van Kollenburg
Best, 5683 AE, Netherlands
Apotheek de Schakel
Best, 5684 ER, Netherlands
Apotheek Heivelden
Best, 5685 HS, Netherlands
Apotheek Blanckenburgh
Beuningen, 6641 DD, Netherlands
Apotheek Bladel
Bladel, 5531 CV, Netherlands
Apotheek Bocholtz
Bocholtz, 6351 ES, Netherlands
Apotheek van de Wouw
Brunssum, 6441 CD, Netherlands
Apotheek Budel
Budel, 6021 HT, Netherlands
Apotheek in 't Groen
Deurne, 5751 BG, Netherlands
Apotheek Koolen-Motké
Deurne, 5751 CB, Netherlands
Apotheek de Schelde
Deurne, 5751 VH, Netherlands
Apotheek Druten
Druten, 6651 DE, Netherlands
Apotheek de Kempen
Eersel, 5521 CA, Netherlands
Apotheek Elsloo
Elsloo, 6181 AS, Netherlands
Apotheek Ewijk
Ewijk, 6644 BR, Netherlands
Apotheek Eygelshoven
Eygelshoven, 6471 JH, Netherlands
Lloyds Apotheek Geldrop
Geldrop, 5664 GG, Netherlands
Apotheek het Frans Brugske
Gemert, 5421 HN, Netherlands
Apotheek Lindner
Gemert, 5421 KW, Netherlands
Apotheek de Duivenakker
Gennep, 6591 CZ, Netherlands
Apotheek Gennep
Gennep, 6591 CZ, Netherlands
Apotheek de Pijlers
Goes, 4461 LT, Netherlands
Zeeuwse Apotheek
Goes, 4462 DZ, Netherlands
Apotheek de Goese Polder
Goes, 4463 VA, Netherlands
Apotheek Groesbeek
Groesbeek, 6562 AH, Netherlands
Linde apotheek
Hapert, 5527 BN, Netherlands
Apotheek Heeswijk-Dinther
Heeswijk-Dinther, 5473 GB, Netherlands
Apotheek Tendijck
Helmond, 5701 HN, Netherlands
Service Apotheek de Bus
Helmond, 5702 HW, Netherlands
Service apotheek Vondellaan
Helmond, 5702 HW, Netherlands
Apotheek de Luifel
Helmond, 5703 GA, Netherlands
Apotheek Brouwhuis
Helmond, 5704 LK, Netherlands
Kring-apotheek de Rijpel
Helmond, 5709 BT, Netherlands
Lloyds Apotheek Herkenbosch
Herkenbosch, 6075 AG, Netherlands
Apotheek Hegtermans
Herten, 6049 BS, Netherlands
Apotheek Herten-Merum
Herten, 6049 ES, Netherlands
apotheek Kerkrade-centrum
Kerkrade, 6461 AL, Netherlands
Apotheek Schonefeld
Kerkrade, 6461 EP, Netherlands
Apotheek Bleijerheide
Kerkrade, 6462 AL, Netherlands
Apotheek Medische Centrum West Kerkrade
Kerkrade, 6466 BR, Netherlands
Apotheek Terwinselen
Kerkrade, 6467 GC, Netherlands
Apotheek Waubach
Landgraaf, 6370 JA, Netherlands
Apotheek Landgraaf
Landgraaf, 6371 BM, Netherlands
Apotheek MC Putstraat
Landgraaf, 6372 BK, Netherlands
Apotheek Schaesberg
Landgraaf, 6372 CN, Netherlands
Apotheek Nieuwenhagen
Landgraaf, 6373 KK, Netherlands
Apotheek Maarheeze
Maarheeze, 6026 ER, Netherlands
Apotheek Craveld
Maasbracht, 6050 AD, Netherlands
Apotheek Maasbracht
Maasbracht, 6050 AD, Netherlands
Service apotheek Malden
Malden, 6581 BG, Netherlands
Apotheek Maasdorpen
Meerlo, 5864 AG, Netherlands
Lloyds Apotheek de Roerstreek
Melick, 6074 AP, Netherlands
Apotheek Ringeling
Middelburg, 4331 AM, Netherlands
Apotheek Hummelen
Middelburg, 4331 LL, Netherlands
Apotheek Stromenwijk 't Zand
Middelburg, 4335 GT, Netherlands
Apotheek Welsinge
Middelburg, 4336 ED, Netherlands
Apotheek Dauwendaele
Middelburg, 4337 JH, Netherlands
Apotheek van der Ploeg
Nijmegen, 6522 CA, Netherlands
Kring-apotheek Beckers
Nijmegen, 6524 DL, Netherlands
Apotheek Souburg
Oost-Souburg, 4388 CC, Netherlands
Lloyds Apotheek Postert
Posterholt, 6061 EG, Netherlands
Apotheek Reusel
Reusel, 5541 CS, Netherlands
Lloyds Apotheek Clemens-Haan
Roermond, 6041 HS, Netherlands
Reinald apotheek
Roermond, 6041 XB, Netherlands
Apotheek Hendrickx-Maasniel
Roermond, 6042 JL, Netherlands
Lloyds Apotheek Donderberg
Roermond, 6043 JR, Netherlands
Apotheek Roermond Zuid
Roermond, 6045 GC, Netherlands
Apotheek Rosmalen-Walschot
Rosmalen, 5241 BL, Netherlands
Apotheek Rosmalen
Rosmalen, 5242 HT, Netherlands
apotheek Simpelveld-Bocholtz
Simpelveld, 6369 VP, Netherlands
Apotheek Hopveld
Sint-Michielsgestel, 5271 XP, Netherlands
Apotheek de Baandert
Sittard, 6136 KE, Netherlands
Wandelbos Apotheek
Tilburg, 5044 PB, Netherlands
Apotheek de Belleman
Valkenswaard, 5551 EW, Netherlands
Apotheek Valkenswaard
Valkenswaard, 5554 CA, Netherlands
Apotheek Vlaslant
Valkenswaard, 5554 HA, Netherlands
Apotheek Dommeldal
Valkenswaard, 5554 RM, Netherlands
apotheek 't Zuid
Veghel, 5463 CP, Netherlands
Veldhovense Apotheek
Veldhoven, 5503 BP, Netherlands
Apotheek Zonderwijk
Veldhoven, 5505 AJ, Netherlands
Apotheek van Poppel
Wijchen, 6601 ZX, Netherlands
Apotheek Dr. H. Kilian
Wijchen, 6602 DB, Netherlands
Apotheek Wijchen-Zuid
Wijchen, 6605 HN, Netherlands
Related Publications (16)
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PMID: 9090699BACKGROUNDAnderson GM, Lexchin J. Strategies for improving prescribing practice. CMAJ. 1996 Apr 1;154(7):1013-7.
PMID: 8625021BACKGROUNDGrimshaw JM, Shirran L, Thomas R, Mowatt G, Fraser C, Bero L, Grilli R, Harvey E, Oxman A, O'Brien MA. Changing provider behavior: an overview of systematic reviews of interventions. Med Care. 2001 Aug;39(8 Suppl 2):II2-45.
PMID: 11583120BACKGROUNDCollins TM, Mott DA, Bigelow WE, Zimmerman DR. A controlled letter intervention to change prescribing behavior: results of a dual-targeted approach. Health Serv Res. 1997 Oct;32(4):471-89.
PMID: 9327814BACKGROUNDMuijrers PE, Knottnerus JA, Sijbrandij J, Janknegt R, Grol RP. Changing relationships: attitudes and opinions of general practitioners and pharmacists regarding the role of the community pharmacist. Pharm World Sci. 2003 Oct;25(5):235-41. doi: 10.1023/a:1025872907411.
PMID: 14584231BACKGROUNDZitman FG, Couvee JE. Chronic benzodiazepine use in general practice patients with depression: an evaluation of controlled treatment and taper-off: report on behalf of the Dutch Chronic Benzodiazepine Working Group. Br J Psychiatry. 2001 Apr;178:317-24. doi: 10.1192/bjp.178.4.317.
PMID: 11282810BACKGROUNDVorma H, Naukkarinen H, Sarna S, Kuoppasalmi K. Long-term outcome after benzodiazepine withdrawal treatment in subjects with complicated dependence. Drug Alcohol Depend. 2003 Jun 5;70(3):309-14. doi: 10.1016/s0376-8716(03)00014-0.
PMID: 12757968BACKGROUNDVoshaar RC, Gorgels WJ, Mol AJ, van Balkom AJ, van de Lisdonk EH, Breteler MH, van den Hoogen HJ, Zitman FG. Tapering off long-term benzodiazepine use with or without group cognitive-behavioural therapy: three-condition, randomised controlled trial. Br J Psychiatry. 2003 Jun;182:498-504. doi: 10.1192/bjp.182.6.498.
PMID: 12777340BACKGROUNDCouvee JE, Timmermans MA, Zitman FG; Dutch Chronic Benzodiazepine Working Group. The long-term outcome of a benzodiazepine discontinuation programme in depressed outpatients. J Affect Disord. 2002 Jul;70(2):133-41. doi: 10.1016/s0165-0327(01)00330-5.
PMID: 12117625BACKGROUNDMol AJ, Oude Voshaar RC, Gorgels WJ, Breteler MH, van Balkom AJ, van de Lisdonk EH, Kan CC, Mulder J, Zitman FG. The absence of benzodiazepine craving in a general practice benzodiazepine discontinuation trial. Addict Behav. 2006 Feb;31(2):211-22. doi: 10.1016/j.addbeh.2005.04.024. Epub 2005 Jun 13.
PMID: 15951127BACKGROUNDMorin CM, Bastien C, Guay B, Radouco-Thomas M, Leblanc J, Vallieres A. Randomized clinical trial of supervised tapering and cognitive behavior therapy to facilitate benzodiazepine discontinuation in older adults with chronic insomnia. Am J Psychiatry. 2004 Feb;161(2):332-42. doi: 10.1176/appi.ajp.161.2.332.
PMID: 14754783BACKGROUNDMcGregor C, Machin A, White JM. In-patient benzodiazepine withdrawal: comparison of fixed and symptom-triggered taper methods. Drug Alcohol Rev. 2003 Jun;22(2):175-80. doi: 10.1080/09595230100100615.
PMID: 12850904BACKGROUNDGorgels WJ, Oude Voshaar RC, Mol AJ, van de Lisdonk EH, van Balkom AJ, van den Hoogen HJ, Mulder J, Breteler MH, Zitman FG. Discontinuation of long-term benzodiazepine use by sending a letter to users in family practice: a prospective controlled intervention study. Drug Alcohol Depend. 2005 Apr 4;78(1):49-56. doi: 10.1016/j.drugalcdep.2004.09.001.
PMID: 15769557BACKGROUNDOude Voshaar RC, Gorgels WJ, Mol AJ, Couvee JE, van Balkom AJ, Zitman FG. [Treatment methods for discontinuation of long-term benzodiazepine use]. Ned Tijdschr Geneeskd. 2001 Jul 14;145(28):1347-50. Dutch.
PMID: 11484431BACKGROUNDCormack MA, Sweeney KG, Hughes-Jones H, Foot GA. Evaluation of an easy, cost-effective strategy for cutting benzodiazepine use in general practice. Br J Gen Pract. 1994 Jan;44(378):5-8.
PMID: 8312045BACKGROUNDvan de Steeg-van Gompel CH, Wensing M, De Smet PA. Implementation of a discontinuation letter to reduce long-term benzodiazepine use--a cluster randomized trial. Drug Alcohol Depend. 2009 Jan 1;99(1-3):105-14. doi: 10.1016/j.drugalcdep.2008.07.009. Epub 2008 Sep 17.
PMID: 18801626DERIVED
Study Officials
- PRINCIPAL INVESTIGATOR
Peter G de Smet, PhD
Scientific Institute for Dutch Pharmacists, The Netherlands
- STUDY DIRECTOR
Michel Wensing, PhD
Centre for Quality of Care Research Nijmegen
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
December 21, 2005
First Posted
December 22, 2005
Study Start
November 1, 2005
Primary Completion
December 1, 2006
Study Completion
December 1, 2006
Last Updated
August 18, 2009
Record last verified: 2009-08