NCT00268554

Brief Summary

The purpose of this study is to determine whether dipyridamole enhances postocclusive reactive hyperaemia by increasing extracellular adenosine concentrations during ischemia and reperfusion. Furthermore we hypothesize that dipyridamole augments postocclusive reactive hyperaemia by increasing adenosine receptor stimulation.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
12

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Dec 2005

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2005

Completed
20 days until next milestone

First Submitted

Initial submission to the registry

December 21, 2005

Completed
1 day until next milestone

First Posted

Study publicly available on registry

December 22, 2005

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2006

Completed
Last Updated

March 28, 2008

Status Verified

March 1, 2008

First QC Date

December 21, 2005

Last Update Submit

March 27, 2008

Conditions

HyperemiaHypoxia

Keywords

adenosinecaffeinedipyridamole

Outcome Measures

Primary Outcomes (1)

  • forearm blood flow

Interventions

dipyridamoleDRUG
caffeineDRUG

Eligibility Criteria

Age18 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • healthy volunteers between 18 and 50 years

You may not qualify if:

  • none specified

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Radboud university Nijmegen Medical Centre

Nijmegen, Gelderland, 6533 ZA, Netherlands

Location

MeSH Terms

Conditions

HyperemiaHypoxia

Interventions

DipyridamoleCaffeine

Condition Hierarchy (Ancestors)

Vascular DiseasesCardiovascular DiseasesSigns and Symptoms, RespiratorySigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

PyrimidinesHeterocyclic Compounds, 1-RingHeterocyclic CompoundsXanthinesAlkaloidsPurinonesPurinesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-Ring

Study Officials

  • Gerard Rongen, MD,PhD

    Radboud University Medical Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER

Study Record Dates

First Submitted

December 21, 2005

First Posted

December 22, 2005

Study Start

December 1, 2005

Study Completion

July 1, 2006

Last Updated

March 28, 2008

Record last verified: 2008-03

Locations

NL(1)