NCT00267267

Brief Summary

The Torcetrapib project was terminated on December 2, 2006 due to safety findings. Cholesterol levels will be measured over six weeks in subjects being treated with two different kinds of combination cholesterol medications to see how the different treatments compare to one another.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,784

participants targeted

Target at P75+ for phase_3

Timeline
Completed

Started Jan 2006

Shorter than P25 for phase_3

Geographic Reach
1 country

123 active sites

Status
terminated

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 19, 2005

Completed
1 day until next milestone

First Posted

Study publicly available on registry

December 20, 2005

Completed
12 days until next milestone

Study Start

First participant enrolled

January 1, 2006

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2007

Completed
Last Updated

December 10, 2007

Status Verified

December 1, 2006

First QC Date

December 19, 2005

Last Update Submit

December 6, 2007

Conditions

Outcome Measures

Primary Outcomes (1)

  • Percent change in LDL-C and HDL-C from baseline, after six weeks of treatment.

Secondary Outcomes (1)

  • Changes in other lipid parameters and other biomarkers.

Interventions

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Specific LDL-C levels based on CHD risk after a six-week washout period.

You may not qualify if:

  • Women who are pregnant or lactating, or planning to become pregnant.
  • Subjects taking any drugs known to be associated with an increased risk of myositis in combination with HMG-CoA reductase inhibitors.
  • Subjects requiring systemic steroids
  • Subjects with any other medical condition or laboratory abnormality which could affect subject safety, preclude evaluation of response, or render unlikely that the subject would complete the study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (123)

Pfizer Investigational Site

Birmingham, Alabama, 35209-7802, United States

Location

Pfizer Investigational Site

Birmingham, Alabama, 35235, United States

Location

Pfizer Investigational Site

Chandler, Arizona, 85224, United States

Location

Pfizer Investigational Site

Mesa, Arizona, 85201, United States

Location

Pfizer Investigational Site

Jonesboro, Arkansas, 72401, United States

Location

Pfizer Investigational Site

Anaheim, California, 92804, United States

Location

Pfizer Investigational Site

Escondido, California, 92025-4284, United States

Location

Pfizer Investigational Site

Fresno, California, 93720, United States

Location

Pfizer Investigational Site

Los Altos, California, 94024, United States

Location

Pfizer Investigational Site

Los Angeles, California, 90015, United States

Location

Pfizer Investigational Site

Palm Springs, California, 92262, United States

Location

Pfizer Investigational Site

Paramount, California, 90723, United States

Location

Pfizer Investigational Site

San Diego, California, 92128, United States

Location

Pfizer Investigational Site

Santa Rose, California, 95405, United States

Location

Pfizer Investigational Site

Walnut Creek, California, 94598, United States

Location

Pfizer Investigational Site

Westlake Village, California, 91361, United States

Location

Pfizer Investigational Site

Golden, Colorado, 80401, United States

Location

Pfizer Investigational Site

New Haven, Connecticut, 06519-1600, United States

Location

Pfizer Investigational Site

Newark, Delaware, 19713, United States

Location

Pfizer Investigational Site

Washington D.C., District of Columbia, 20010, United States

Location

Pfizer Investigational Site

Atlantis, Florida, 33462, United States

Location

Pfizer Investigational Site

Boca Raton, Florida, 33486, United States

Location

Pfizer Investigational Site

Daytona Beach, Florida, 32114, United States

Location

Pfizer Investigational Site

DeFuniak Springs, Florida, 32435, United States

Location

Pfizer Investigational Site

Destin, Florida, 32541, United States

Location

Pfizer Investigational Site

Lakeland, Florida, 33805, United States

Location

Pfizer Investigational Site

Miami, Florida, 33136, United States

Location

Pfizer Investigational Site

Miami, Florida, 33144, United States

Location

Pfizer Investigational Site

Miami, Florida, 33173, United States

Location

Pfizer Investigational Site

Orlando, Florida, 32806, United States

Location

Pfizer Investigational Site

Pensacola, Florida, 32504-8721, United States

Location

Pfizer Investigational Site

Atlanta, Georgia, 30309, United States

Location

Pfizer Investigational Site

Atlanta, Georgia, 30328, United States

Location

Pfizer Investigational Site

Atlanta, Georgia, 30342, United States

Location

Pfizer Investigational Site

Honolulu, Hawaii, 96814, United States

Location

Pfizer Investigational Site

Aurora, Illinois, 60504, United States

Location

Pfizer Investigational Site

Chicago, Illinois, 60637, United States

Location

Pfizer Investigational Site

Rockford, Illinois, 61108, United States

Location

Pfizer Investigational Site

Springfield, Illinois, 62701, United States

Location

Pfizer Investigational Site

Evansville, Indiana, 47712, United States

Location

Pfizer Investigational Site

Evansville, Indiana, 47713, United States

Location

Pfizer Investigational Site

Evansville, Indiana, 47714, United States

Location

Pfizer Investigational Site

Des Moines, Iowa, 50314, United States

Location

Pfizer Investigational Site

Newton, Kansas, 67114, United States

Location

Pfizer Investigational Site

Overland Park, Kansas, 66210, United States

Location

Pfizer Investigational Site

Pratt, Kansas, 67124, United States

Location

Pfizer Investigational Site

Topeka, Kansas, 66606, United States

Location

Pfizer Investigational Site

Edgewood, Kentucky, 41017, United States

Location

Pfizer Investigational Site

Erlanger, Kentucky, 41018, United States

Location

Pfizer Investigational Site

Louisville, Kentucky, 40205-3374, United States

Location

Pfizer Investigational Site

Columbia, Maryland, 21044-2914, United States

Location

Pfizer Investigational Site

Ayer, Massachusetts, 01432, United States

Location

Pfizer Investigational Site

Boston, Massachusetts, 02111, United States

Location

Pfizer Investigational Site

Boston, Massachusetts, 02114, United States

Location

Pfizer Investigational Site

Milford, Massachusetts, 01757, United States

Location

Pfizer Investigational Site

Bloomfield Hills, Michigan, 48302, United States

Location

Pfizer Investigational Site

Grand Rapids, Michigan, 49525, United States

Location

Pfizer Investigational Site

Troy, Michigan, 48098, United States

Location

Pfizer Investigational Site

Brooklyn Center, Minnesota, 55430, United States

Location

Pfizer Investigational Site

Edina, Minnesota, 55435, United States

Location

Pfizer Investigational Site

Saint Cloud, Minnesota, 56303-1901, United States

Location

Pfizer Investigational Site

Columbia, Missouri, 65212, United States

Location

Pfizer Investigational Site

Jefferson City, Missouri, 65109, United States

Location

Pfizer Investigational Site

Manchester, Missouri, 63021, United States

Location

Pfizer Investigational Site

Springfield, Missouri, 65804, United States

Location

Pfizer Investigational Site

Springfield, Missouri, 65807, United States

Location

Pfizer Investigational Site

Omaha, Nebraska, 68106, United States

Location

Pfizer Investigational Site

Omaha, Nebraska, 68114, United States

Location

Pfizer Investigational Site

Omaha, Nebraska, 68130, United States

Location

Pfizer Investigational Site

Las Vegas, Nevada, 89106, United States

Location

Pfizer Investigational Site

Las Vegas, Nevada, 89128, United States

Location

Pfizer Investigational Site

Cooperstown, New York, 13326, United States

Location

Pfizer Investigational Site

Endwell, New York, 13760, United States

Location

Pfizer Investigational Site

Lewiston, New York, 14092, United States

Location

Pfizer Investigational Site

Manlius, New York, 13104, United States

Location

Pfizer Investigational Site

Rochester, New York, 14609, United States

Location

Pfizer Investigational Site

Rochester, New York, 14618, United States

Location

Pfizer Investigational Site

Syracuse, New York, 13202, United States

Location

Pfizer Investigational Site

West Seneca, New York, 14224, United States

Location

Pfizer Investigational Site

Cary, North Carolina, 27511, United States

Location

Pfizer Investigational Site

Charlotte, North Carolina, 28209-3734, United States

Location

Pfizer Investigational Site

Huntersville, North Carolina, 28078, United States

Location

Pfizer Investigational Site

Monroe, North Carolina, 28112, United States

Location

Pfizer Investigational Site

Raleigh, North Carolina, 27609, United States

Location

Pfizer Investigational Site

Wilmington, North Carolina, 28412, United States

Location

Pfizer Investigational Site

Winston-Salem, North Carolina, 27103-3315, United States

Location

Pfizer Investigational Site

Winston-Salem, North Carolina, 27103, United States

Location

Pfizer Investigational Site

Cincinnati, Ohio, 45219, United States

Location

Pfizer Investigational Site

Cleveland, Ohio, 44195, United States

Location

Pfizer Investigational Site

Fairview Park, Ohio, 44126, United States

Location

Pfizer Investigational Site

Beaver, Pennsylvania, 15009, United States

Location

Pfizer Investigational Site

Bensalem, Pennsylvania, 19020, United States

Location

Pfizer Investigational Site

Doylestown, Pennsylvania, 18901, United States

Location

Pfizer Investigational Site

Harleysville, Pennsylvania, 19438, United States

Location

Pfizer Investigational Site

Lancaster, Pennsylvania, 17603, United States

Location

Pfizer Investigational Site

Pittsburgh, Pennsylvania, 15213, United States

Location

Pfizer Investigational Site

Pittsburgh, Pennsylvania, 15224, United States

Location

Pfizer Investigational Site

Sayre, Pennsylvania, 18840, United States

Location

Pfizer Investigational Site

Lincoln, Rhode Island, 02865, United States

Location

Pfizer Investigational Site

Providence, Rhode Island, 02906, United States

Location

Pfizer Investigational Site

Anderson, South Carolina, 29621, United States

Location

Pfizer Investigational Site

Mt. Pleasant, South Carolina, 29464, United States

Location

Pfizer Investigational Site

Simpsonville, South Carolina, 29681, United States

Location

Pfizer Investigational Site

Bristol, Tennessee, 37620, United States

Location

Pfizer Investigational Site

Chattanooga, Tennessee, 37404, United States

Location

Pfizer Investigational Site

Germantown, Tennessee, 38138, United States

Location

Pfizer Investigational Site

Johnson City, Tennessee, 37601, United States

Location

Pfizer Investigational Site

Memphis, Tennessee, 38104, United States

Location

Pfizer Investigational Site

Memphis, Tennessee, 38119, United States

Location

Pfizer Investigational Site

Memphis, Tennessee, 38120, United States

Location

Pfizer Investigational Site

Memphis, Tennessee, 38128, United States

Location

Pfizer Investigational Site

Selmer, Tennessee, 38375, United States

Location

Pfizer Investigational Site

Arlington, Texas, 76017, United States

Location

Pfizer Investigational Site

Houston, Texas, 77030, United States

Location

Pfizer Investigational Site

Houston, Texas, 77054, United States

Location

Pfizer Investigational Site

San Antonio, Texas, 78229, United States

Location

Pfizer Investigational Site

San Antonio, Texas, 78238, United States

Location

Pfizer Investigational Site

Bountiful, Utah, 84010, United States

Location

Pfizer Investigational Site

Salt Lake City, Utah, 84102, United States

Location

Pfizer Investigational Site

Newport News, Virginia, 23606, United States

Location

Pfizer Investigational Site

Norfolk, Virginia, 23502, United States

Location

Pfizer Investigational Site

Renton, Washington, 98055, United States

Location

Pfizer Investigational Site

Spokane, Washington, 99216, United States

Location

MeSH Terms

Conditions

HyperlipidemiasDyslipidemias

Interventions

torcetrapibAtorvastatinEzetimibe, Simvastatin Drug Combination

Condition Hierarchy (Ancestors)

Lipid Metabolism DisordersMetabolic DiseasesNutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

PyrrolesAzolesHeterocyclic Compounds, 1-RingHeterocyclic CompoundsHeptanoic AcidsFatty AcidsLipidsSimvastatinLovastatinNaphthalenesPolycyclic Aromatic HydrocarbonsHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbonsOrganic ChemicalsEzetimibeAzetidinesAzetinesPolycyclic CompoundsDrug CombinationsPharmaceutical Preparations

Study Officials

  • Pfizer CT.gov Call Center

    Pfizer

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
DOUBLE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

December 19, 2005

First Posted

December 20, 2005

Study Start

January 1, 2006

Study Completion

January 1, 2007

Last Updated

December 10, 2007

Record last verified: 2006-12

Locations