Exercise and Physical Fitness for Persons With Knee Osteoarthritis

NCT00265447 | Completed Phase 3

• 1 other identifier: H133B031120-Proj 2
• Study Type: interventional
• Target: 55
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this project is to establish evidence to support specific, targeted exercise and rehabilitation recommendations for people over 50 with osteoarthritis of the knee.

Conditions

Knee Osteoarthritis

Keywords

knee osteoarthritis; exercise; aerobic exercise; strengthening exercise; exercise prescription; rehabilitation; physical disability; physical function; physical activity; physical fitness

Outcome Measures

Primary Outcomes (2)

• WOMAC Pain scale

  baseline, 3 months, and 6 months

• WOMAC physical function scale, muscle performance,flexibility, aerobic capacity, self-reported health status

  baseline, 3 months, 6 months

Secondary Outcomes (1)

• AIMS2

  baseline, 3 months, 6 months

Study Arms (3)

Strength training

ACTIVE COMPARATOR

3 months of strength training

Behavioral: Strength training

Aerobic conditioning

ACTIVE COMPARATOR

3 months of aerobic conditioning

Behavioral: Aerobic conditioning

Delayed exercise

OTHER

delayed exercise control group

Behavioral: Delayed exercise

Interventions

Strength training BEHAVIORAL

3 months of strength training

Strength training

Aerobic conditioning BEHAVIORAL

3 months of aerobic conditioning

Aerobic conditioning

Delayed exercise BEHAVIORAL

delayed exercise control group

Delayed exercise

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• community-dwelling, physician diagnosed osteoarthritis of the knee, willingness to exercise regularly, willingness to perform 3 testing sessions over a 6-month period, ability to exercise safely at a moderate level of intensity, knee osteoarthritis by clinical criteria,
• WOMAC Scores as follows:
• PAIN:"mild" pain on 2 items or "moderate" pain on 1 item; PHYSICAL FUNCTION: "mild" difficulty in 4 items or "moderate" difficulty in 2 items -

You may not qualify if:

• age\<50,inability to exercise and ambulate independently, physical limitation secondary to a condition that is not modifiable by exercise (e.g., active cancer), knee replacement (past or scheduled), total hip joint replacement less than 6 months ago, current participation in regular conditioning exercise, participation in another research study,

Sponsors & Collaborators

• University of Missouri-Columbia: lead
• U.S. Department of Education: collaborator

Study Sites (1)

University of Missouri

Columbia, Missouri, 65211, United States

Location

MeSH Terms

Conditions

Osteoarthritis, Knee; Motor Activity

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Behavior

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Marian A Minor, PhD

  Department of Physical Therapy, School of Health Professions, University of Missouri-Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 13, 2005
• First Posted: December 14, 2005
• Study Start: December 1, 2005
• Primary Completion: July 1, 2011
• Study Completion: July 1, 2011
• Last Updated: September 28, 2016

Record last verified: 2016-09

Locations

US (1)