NCT00260897

Brief Summary

Avascular necrosis of the femoral head (ANFH) is a debilitating disease that commonly leads to destruction of the hip joint in patients at middle age of life and often requires surgical intervention. Previously, we have identified the collagen type II, alpha 1 (COL2A1) gene as the ANFH disease gene. In this grant proposal, we will establish cell ine and animal models to understand the pathophysiology of ANFH, and extend our ongoing study for identifying genes responsible for non-familiar ANFH by looking into other interacting molecules of the pathway.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
500

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started May 2003

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2003

Completed
2.6 years until next milestone

First Submitted

Initial submission to the registry

December 1, 2005

Completed
1 day until next milestone

First Posted

Study publicly available on registry

December 2, 2005

Completed
2.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2008

Completed
Last Updated

May 8, 2007

Status Verified

May 1, 2007

First QC Date

December 1, 2005

Last Update Submit

May 7, 2007

Conditions

Osteonecrosis

Keywords

avascular necrosis of the femoral headgenotypinglinkage analysispathogenesistherapy

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • \- avascular necrosis of the femoral head

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Division of Molecular and Genomic Medicine, National Health Research Institutes

Miaoli County, 350, Taiwan

RECRUITING

Related Links

MeSH Terms

Conditions

OsteonecrosisFemur Head Necrosis

Condition Hierarchy (Ancestors)

Bone DiseasesMusculoskeletal DiseasesNecrosisPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Wei-Ming Chen, M.D.

    Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Shih-Feng Tsai, M.D., Ph.D.

CONTACT

(886)-37-246-166petsai@nhri.org.tw

Study Design

Study Type
observational
Observational Model
DEFINED POPULATION
Time Perspective
OTHER
Sponsor Type
OTHER

Study Record Dates

First Submitted

December 1, 2005

First Posted

December 2, 2005

Study Start

May 1, 2003

Study Completion

April 1, 2008

Last Updated

May 8, 2007

Record last verified: 2007-05

Locations

TW(1)