NCT00256620|Completed
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Sponsor study identifier
interventional
412
1 country
1
Study Start
December 1996
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
December 1999
Date type not reportedThis date has not been verified as actual or estimated.
The principal objective to this randomized trial is to compare the efficacy of two strategies of intra-operative hemodynamic management during cardiopulmonary bypass among patients undergoing primary elective coronary artery bypass graft (CABG) surgery in preventing peri-operative cardiac, cognitive and neurologic morbidity and mortality and post-operative deterioration in the patient's quality of life as measured by the seven domains of SF-36 Health Survey (bodily pain, health perceptions, energy, and mental, physical, social and role function).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 1999
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 1996
Date type not reportedThis date has not been verified as actual or estimated.
December 1999
Date type not reportedThis date has not been verified as actual or estimated.
November 17, 2005
Actual (reported)November 21, 2005
Actual (reported)Quality of life
Cardiac morbidity
Neurologic morbidity
Mortality
Neurocognitive deterioration
• To evaluate the prognostic importance of severe atheromatous disease of the descending aorta as found on transesophageal echocardiography (TEE) as a predictor of neurologic events.
• To correlate TEE and epiaortic scanning for aortic atheroma with transthoracic echocardiography (TTE) in order to develop a non-invasive screening tool.
• To assess the clinical significance of persistent post-operative depression as measured by the CES-D by using a structured clinical interview and to evaluate the relationship between pre-operative depression and the occurrence of cardiac, neurologic a
• To provide data on the mechanism of perioperative neurologic and cognitive complications in order to design other specific intervention to reduce postoperative morbidity.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
New York Presbyterian Hospital-Weill Medical Center
New York, New York, 10021, United States
Mary E Charlson, MD
Weill Medical College of Cornell University
Karl Krieger, MD
Weill Medical College of Cornell University
First Submitted
November 17, 2005
First Posted
November 21, 2005
Study Start
December 1996
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
December 1999
Date type not reportedContact the study team to confirm eligibility.
This date has not been verified as actual or estimated.
Last Updated
April 3, 2008
Record last verified: 2008-03
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Source: ClinicalTrials.gov.
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