Psychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure

NCT00255411 | Completed

• 2 other identifiers: 06002706-N-0027
• Study Type: observational
• Target: 190
• Locations: 1 country
• Sites: 1

Brief Summary

This study will explore how the mind and the brain work to cause movement symptoms or seizures in people who do not have a recognized neurological or medical disorder. The study includes a check for psychiatric disorders, symptoms and their severity; psychiatric and personality questionnaires; and neuropsychological testing. Normal, healthy volunteers, people who have movement symptoms not due to a brain or medical disorder and people who have seizures not due to epilepsy may be eligible for this study. All candidates must be 18 years of age or older. All participants have a medical history, physical examination and psychological evaluation, including completion of questionnaires. People with movement symptoms or seizures have a symptoms evaluation. Some participants also undergo neuropsychological testing, including questionnaires, pen-and-paper or computerized tests, and motor tasks.

Conditions

Psychogenic Movement Disorders; Non-epileptic Seizures

Keywords

Conversion Disorder; Somatoform Disorder; Involuntary Movement; Childhood Abuse; Depression; Psychogenic Movement Disorder; PMD; Non-Epileptic Seizure; NES; Healthy Volunteer; HV

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients for dissociation study:
• Diagnosis of clinically definite PMD utilizing Fahn and Williams criteria. The diagnosis will be made by a movement disorders neurologist.
• Or a diagnosis of NES based on video-EEG. The diagnosis will be made by an epileptologist.
• Males or females
• Age 18 or older
• Able to provide informed consent
• Patients for cognitive study:
• Diagnosis of clinically definite PMD utilizing Fahn and Williams criteria. The diagnosis will be made by a movement disorders neurologist.
• Age 18 or older
• Males or females
• Able to provide informed consent
• Normal volunteers for cognitive study:
• Normal volunteers age 18 or older will be included
• Males or females
• Able to provide informed consent

You may not qualify if:

• Patients for dissociation study:
• Diagnosis of probable or possible PMD using Fahn and Williams criteria.
• Patients with neurological disorders with elaboration of their underlying disease process including comorbid epilepsy.
• Patients with a medical condition that prevents them from taking part in the study.
• Patients with current suicidal ideation.
• Patients with a psychotic disorder.
• Patients with active substance abuse within the last 6 months.
• Patients below the age of 18.
• Patients who are not capable of consent.
• Patients with an IQ less than 55.
• Patients currently involved in lawsuits.
• Patients for cognitive study:
• Diagnosis of probable or possible PMD using Fahn and Williams criteria
• Patients with neurological disorders with elaboration of their underlying disease process including comorbid epilepsy
• Patients with a medical condition that prevents them from taking part in the study.

Sponsors & Collaborators

• National Institute of Neurological Disorders and Stroke (NINDS): lead

Study Sites (1)

National Institutes of Health Clinical Center, 9000 Rockville Pike

Bethesda, Maryland, 20892, United States

Location

Related Publications (3)

• Williams DT, Ford B, Fahn S. Phenomenology and psychopathology related to psychogenic movement disorders. Adv Neurol. 1995;65:231-57. No abstract available.

  PMID: 7872143 BACKGROUND

• Carson AJ, Ringbauer B, Stone J, McKenzie L, Warlow C, Sharpe M. Do medically unexplained symptoms matter? A prospective cohort study of 300 new referrals to neurology outpatient clinics. J Neurol Neurosurg Psychiatry. 2000 Feb;68(2):207-10. doi: 10.1136/jnnp.68.2.207.

  PMID: 10644789 BACKGROUND

• Stone J, Carson A, Sharpe M. Functional symptoms and signs in neurology: assessment and diagnosis. J Neurol Neurosurg Psychiatry. 2005 Mar;76 Suppl 1(Suppl 1):i2-12. doi: 10.1136/jnnp.2004.061655. No abstract available.

  PMID: 15718217 BACKGROUND

MeSH Terms

Conditions

Seizures; Conversion Disorder; Somatoform Disorders; Dyskinesias; Depression

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Mental Disorders; Movement Disorders; Central Nervous System Diseases; Behavioral Symptoms; Behavior

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: November 17, 2005
• First Posted: November 18, 2005
• Study Start: November 9, 2005
• Study Completion: February 24, 2009
• Last Updated: July 2, 2017

Record last verified: 2009-02-24

Locations

US (1)