NCT00254527

Brief Summary

The intent of this study is to:

  1. 1.Define the prevalence of MRSA carriage in the pediatric population in Kansas City.
  2. 2.Systematically define patient risk factors for MRSA carriage and infection.
  3. 3.Characterize the unique genetic characteristics of MRSA strains, both community acquired (CA) and healthcare associated (HCA) that are present in the different pediatric populations.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
477

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2005

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2005

Completed
11 months until next milestone

First Submitted

Initial submission to the registry

November 14, 2005

Completed
2 days until next milestone

First Posted

Study publicly available on registry

November 16, 2005

Completed
1.4 years until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2007

Completed
Last Updated

May 2, 2007

Status Verified

November 1, 2005

First QC Date

November 14, 2005

Last Update Submit

April 30, 2007

Conditions

Methicillin ResistanceStaphylococcus Aureus

Keywords

Methicillin Resistant Staphylococcus aureusChildrenColonizationRisk Factor

Eligibility Criteria

Age3 Months - 12 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)

You may qualify if:

  • Colonization:
  • \- Children ages 3 months to 12 years
  • Invasive:
  • \- Invasive MRSA infection

You may not qualify if:

  • Colonization:
  • None
  • Invasive:
  • Those without invasive MRSA infection

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108, United States

Location

Related Publications (13)

  • Wadlvogel FA. Staphylococcus aureus. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and Practice of Infectious Diseases. 5th ed. Philadelphia: Churchill Livingstone, 2000. p.2072-3

    BACKGROUND

  • Kirby WM. EXTRACTION OF A HIGHLY POTENT PENICILLIN INACTIVATOR FROM PENICILLIN RESISTANT STAPHYLOCOCCI. Science. 1944 Jun 2;99(2579):452-3. doi: 10.1126/science.99.2579.452.

    PMID: 17798398BACKGROUND

  • ROZWADOWSKA-DOWZENKO M, LAMERS H. [Infection by penicillin resistant staphylococci]. Pol Tyg Lek (Wars). 1951 May 7;6(18-19):613-7. No abstract available. Undetermined Language.

    PMID: 14875525BACKGROUND

  • Ross S, Rodriguez W, Controni G, Khan W. Staphylococcal susceptibility to penicillin G. The changing pattern among community strains. JAMA. 1974 Aug 19;229(8):1075-7. No abstract available.

    PMID: 4276728BACKGROUND

  • Gross-Schulman S, Dassey D, Mascola L, Anaya C. Community-acquired methicillin-resistant Staphylococcus aureus. JAMA. 1998 Aug 5;280(5):421-2. No abstract available.

    PMID: 9701074BACKGROUND

  • L'Heriteau F, Lucet JC, Scanvic A, Bouvet E. Community-acquired methicillin-resistant Staphylococcus aureus and familial transmission. JAMA. 1999 Sep 15;282(11):1038-9. doi: 10.1001/jama.282.11.1038. No abstract available.

    PMID: 10493201BACKGROUND

  • Centers for Disease Control and Prevention (CDC). Four pediatric deaths from community-acquired methicillin-resistant Staphylococcus aureus - Minnesota and North Dakota, 1997-1999. MMWR Morb Mortal Wkly Rep. 1999 Aug 20;48(32):707-10.

    PMID: 21033181BACKGROUND

  • Bartlett PC, Martin RJ, Cahill BR. Furunculosis in a high school football team. Am J Sports Med. 1982 Nov-Dec;10(6):371-4. doi: 10.1177/036354658201000611.

    PMID: 7180958BACKGROUND

  • Lindenmayer JM, Schoenfeld S, O'Grady R, Carney JK. Methicillin-resistant Staphylococcus aureus in a high school wrestling team and the surrounding community. Arch Intern Med. 1998 Apr 27;158(8):895-9. doi: 10.1001/archinte.158.8.895.

    PMID: 9570176BACKGROUND

  • Thorell E, Jackson MA, Bratcher D, Swanson DS, Selvarangan R. Antimicrobial Resistance of Staphylococcus aureus from Kansas City Children: What is the Appropriate Current Therapy for Pediatric Staphylococcal Infections? 42nd Annual Meeting of Infectious Diseases Society of America, Boston, Sept 30- Oct 3, 2004

    BACKGROUND

  • Chambers HF. The changing epidemiology of Staphylococcus aureus? Emerg Infect Dis. 2001 Mar-Apr;7(2):178-82. doi: 10.3201/eid0702.010204.

    PMID: 11294701BACKGROUND

  • Hussain FM, Boyle-Vavra S, Daum RS. Community-acquired methicillin-resistant Staphylococcus aureus colonization in healthy children attending an outpatient pediatric clinic. Pediatr Infect Dis J. 2001 Aug;20(8):763-7. doi: 10.1097/00006454-200108000-00009.

    PMID: 11734738BACKGROUND

  • McDougal LK, Steward CD, Killgore GE, Chaitram JM, McAllister SK, Tenover FC. Pulsed-field gel electrophoresis typing of oxacillin-resistant Staphylococcus aureus isolates from the United States: establishing a national database. J Clin Microbiol. 2003 Nov;41(11):5113-20. doi: 10.1128/JCM.41.11.5113-5120.2003.

    PMID: 14605147BACKGROUND

MeSH Terms

Conditions

Staphylococcal Infections

Condition Hierarchy (Ancestors)

Gram-Positive Bacterial InfectionsBacterial InfectionsBacterial Infections and MycosesInfections

Study Officials

  • Emily A Thorell, MD

    Children's Mercy Hospital Kansas City

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Time Perspective
OTHER
Sponsor Type
OTHER

Study Record Dates

First Submitted

November 14, 2005

First Posted

November 16, 2005

Study Start

January 1, 2005

Study Completion

April 1, 2007

Last Updated

May 2, 2007

Record last verified: 2005-11

Locations

US(1)