Exercise in Men Receiving Radiation Therapy for Prostate Cancer.
3 other identifiers
interventional
121
1 country
1
Brief Summary
Androgen Deprivation Therapy is a commonly used treatment for men with Prostate Cancer. Unfortunately this can lead to functional decline, fatigue, increased body fatness, loss of lean body tissue and impaired QOL. Previous research has demonstrated the exercise can may reduce fatigue and improve QOL in men on ADT. This study will evaluate whether aerobic versus resistance exercise over a 24 week period of training will reduce morbidity and improve QOL in men receiving radiation plus or minus ADT with curative intent
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jun 2002
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2002
CompletedFirst Submitted
Initial submission to the registry
November 10, 2005
CompletedFirst Posted
Study publicly available on registry
November 15, 2005
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2009
CompletedApril 21, 2020
April 1, 2020
7.1 years
November 10, 2005
April 18, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Fatigue- FACT F
24 weeks
Secondary Outcomes (1)
Toxicity of Radiotherapy Body Composition Muscular Fitness Cardiorespiratory Fitness Metabolic Fitness Prostate Specific QOL
24 weeks
Study Arms (3)
Control Arm
NO INTERVENTIONNo exercise measured
Aerobic cardiovascular exercise program
EXPERIMENTALAerobic cardiovascular exercise program
Resistance Exercise Program
EXPERIMENTALResistance Exercise Program
Interventions
Aerobic cardiovascular exercise program
Eligibility Criteria
You may qualify if:
- Prostate Cancer
- Radiation Therapy with curative Intent
- ADT
You may not qualify if:
- Contraindication to exercise
- Uncontrolled hypertension
- Uncontrolled Cardiac Disease
- Uncontrolled psychotic condition
- Unable to obtain informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Ottawa Hospital Research Institutelead
- Canadian Cancer Trials Groupcollaborator
Study Sites (1)
The Ottawa Hospital-Integrated Cancer Program
Ottawa, Ontario, K1H-1C4, Canada
Related Publications (1)
Segal RJ, Reid RD, Courneya KS, Malone SC, Parliament MB, Scott CG, Venner PM, Quinney HA, Jones LW, D'Angelo ME, Wells GA. Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. J Clin Oncol. 2003 May 1;21(9):1653-9. doi: 10.1200/JCO.2003.09.534.
PMID: 12721238RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Roanne Segal
OHRI
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 10, 2005
First Posted
November 15, 2005
Study Start
June 1, 2002
Primary Completion
July 1, 2009
Study Completion
July 1, 2009
Last Updated
April 21, 2020
Record last verified: 2020-04