NCT00252863

Brief Summary

The purpose of this study is to determine whether Symbicort dosed according to the Symbicort Maintenance and Reliever Therapy (SMART) concept is superior to standard asthma treatment according to the local German treatment guidelines.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,600

participants targeted

Target at P75+ for phase_3 asthma

Timeline
Completed

Started Dec 2004

Geographic Reach
1 country

169 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2004

Completed
12 months until next milestone

First Submitted

Initial submission to the registry

November 14, 2005

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 15, 2005

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2006

Completed
Last Updated

March 17, 2009

Status Verified

March 1, 2009

First QC Date

November 14, 2005

Last Update Submit

March 16, 2009

Conditions

Outcome Measures

Primary Outcomes (1)

  • Time to first severe asthma exacerbation

Secondary Outcomes (11)

  • Number of severe asthma exacerbations

  • Mean use of as-needed medication

  • Change in forced expiratory volume in 1 second (FEV1) from the end of run-in to the end of the study period

  • Prescribed asthma medication during the treatment period

  • Asthma Control Questionnaire (ACQ)

  • +6 more secondary outcomes

Interventions

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients with asthma, either well-controlled on a regular therapy with a combination of long-acting beta-agonists and inhaled corticosteroids or symptomatic on therapy with inhaled corticosteroids alone.

You may not qualify if:

  • Any other significant lung disease other than asthma
  • Any disease that might put patients at risk if they participate in the study

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (169)

Research Site

Stuttgart, Baden-Wurttemberg, Germany

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München, Bavaria, Germany

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Cottbus, Brandenburg, Germany

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Hamburg, Hamburg, Germany

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Frankfurt am Main, Hesse, Germany

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Hanover, Lower Saxony, Germany

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Rostock, Mecklenburg-Vorpommern, Germany

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Düsseldorf, North Rhine-Westphalia, Germany

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Münster, North Rhine-Westphalia, Germany

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Mainz, Rhineland-Palatinate, Germany

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Saarbrücken, Saarland, Germany

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Dresden, Saxony, Germany

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Halle, Saxony-Anhalt, Germany

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Bad Segeberg, Schleswig-Holstein, Germany

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Berlin, State of Berlin, Germany

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Jena-Maua, Thuringia, Germany

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Amberg, Germany

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Aschaffenburg, Germany

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Auerbach, Germany

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Augsburg, Germany

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Backnang, Germany

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Bad Arolsen, Germany

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Bad Doberan, Germany

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Bad Lippspringe, Germany

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Bad Neuenahr, Germany

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Bad Reichenhall, Germany

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Bad Sessendorf, Germany

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Bayreuth, Germany

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Bensheim, Germany

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Bergisch Gladbach, Germany

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Berlin, Germany

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Bitte Eintragen, Germany

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Bochum, Germany

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Bonn, Germany

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Borna, Germany

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Brake, Germany

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Burg, Germany

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Burgwedel, Germany

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Castrop-Rauxel, Germany

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Chemnitz, Germany

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Cologne, Germany

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Coswig, Germany

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Cottbus, Germany

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Damme, Germany

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Darmstadt, Germany

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Deggendorf, Germany

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Dillingen, Germany

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Dinslaken, Germany

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Dortmund, Germany

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Dresden, Germany

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Dülmen, Germany

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Düsseldorf, Germany

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Eisenach, Germany

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Eisenhüttenstadt, Germany

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Emden, Germany

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Erfurt, Germany

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Erkelenz, Germany

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Eschwege, Germany

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Flensburg, Germany

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Forchheim, Germany

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Frankenthal, Germany

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Frankfurt, Germany

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Freiberg, Germany

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Freiburg im Breisgau, Germany

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Freising, Germany

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Fulda, Germany

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Fürstenwalde, Germany

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Fürth, Germany

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Gelsenkirchen, Germany

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Giessen, Germany

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Gotha, Germany

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Göppingen, Germany

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Günzburg, Germany

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Gütersloh, Germany

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Hagen, Germany

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Halle, Germany

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Hamburg, Germany

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Hamm, Germany

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Hanover, Germany

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Harpstedt, Germany

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Hartha, Germany

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Heidelberg, Germany

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Heilbronn, Germany

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Homburg-Saar, Germany

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Hoyerswerda, Germany

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Iserloh, Germany

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Kamen, Germany

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Kamenz, Germany

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Kamp-Lintfort, Germany

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Karlsruhe, Germany

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Kassel, Germany

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Kaufbeuren, Germany

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Kempten, Germany

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Kiel, Germany

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Kitzingen, Germany

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Koblenz, Germany

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Krefeld, Germany

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Kronach, Germany

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Landsberg, Germany

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Leipzig, Germany

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Leonberg, Germany

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Leverkusen, Germany

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Loerrach, Germany

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Ludwigsburg, Germany

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Lübeck, Germany

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Lüneburg, Germany

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Magdeburg, Germany

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Mainaschaff, Germany

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Mainz, Germany

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Marburg, Germany

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Markkleeberg, Germany

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Memmingen, Germany

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Moers, Germany

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Mönchengladbach, Germany

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Mühlhausen, Germany

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München, Germany

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Neubrandenburg, Germany

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Neuss, Germany

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Neuwied, Germany

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Niesky, Germany

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Nordhausen, Germany

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Oberhausen, Germany

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Oranienburg, Germany

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Oschersleben, Germany

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Paderborn, Germany

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Passau, Germany

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Peine, Germany

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Pforzheim, Germany

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Pinneberg, Germany

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Potsdam, Germany

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Ratingen, Germany

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Recklinghausen, Germany

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Regensburg, Germany

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Reutlingen, Germany

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Rheine, Germany

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Rodenbach, Germany

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Rostock, Germany

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Rottweil, Germany

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Rudolstadt, Germany

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Saalfeld, Germany

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Saarbrücken, Germany

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Saarlouis, Germany

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Salzgitter, Germany

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Sangerhausen, Germany

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Schleswig, Germany

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Schwabach, Germany

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Schwäbisch Gmünd, Germany

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Schwerin, Germany

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Siegen, Germany

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Simmern, Germany

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Sindelfingen, Germany

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Singen, Germany

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Solingen, Germany

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Stade, Germany

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Stadthagen, Germany

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Steinhagen, Germany

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Stuttgart, Germany

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Trier, Germany

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Ulm, Germany

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Uttenreuth, Germany

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Wardenburg, Germany

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Wedel, Germany

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Weinheim, Germany

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Weyhe, Germany

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Witten, Germany

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Worpswede, Germany

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Würzburg, Germany

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Zerbst, Germany

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Zwickau, Germany

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MeSH Terms

Conditions

Asthma

Interventions

Budesonide, Formoterol Fumarate Drug CombinationHealth Services Needs and DemandBudesonideFluticasoneTheophyllinemontelukast

Condition Hierarchy (Ancestors)

Bronchial DiseasesRespiratory Tract DiseasesLung Diseases, ObstructiveLung DiseasesRespiratory HypersensitivityHypersensitivity, ImmediateHypersensitivityImmune System Diseases

Intervention Hierarchy (Ancestors)

Formoterol FumarateEthanolaminesAmino AlcoholsAlcoholsOrganic ChemicalsAminesPregnenedionesPregnenesPregnanesSteroidsFused-Ring CompoundsPolycyclic CompoundsDrug CombinationsPharmaceutical PreparationsHealth Services ResearchHealth PlanningHealth Care Economics and OrganizationsDelivery of Health CareHealth Care Quality, Access, and EvaluationAndrostadienesAndrostenesAndrostanesXanthinesAlkaloidsHeterocyclic CompoundsPurinonesPurinesHeterocyclic Compounds, 2-RingHeterocyclic Compounds, Fused-Ring

Study Officials

  • Heinrich Worth, MD

    Klinikum Fürth

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY

Study Record Dates

First Submitted

November 14, 2005

First Posted

November 15, 2005

Study Start

December 1, 2004

Study Completion

May 1, 2006

Last Updated

March 17, 2009

Record last verified: 2009-03

Locations