The Genetic Basis of Atrial Fibrillation (AF)

NCT00248326 | Completed DMC

• 1 other identifier: 0405107
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The investigators' goal with this research is to:

1. 1.Establish a clinical database and a DNA bank for 1000 individuals with AF and 1000 individuals without AF.
2. 2.Directly test the hypothesis that known functional polymorphisms in the coding sequences and the promoter regions of cardiac genes (ion channels and genes known to affect survival in the setting of left ventricular dysfunction) predispose individuals to AF.
3. 3.Increased oversight or intervention of at-risk subjects, which might prevent unnecessary morbidity and mortality due to AF.
4. 4.Further insight into the pathogenesis of AF, which may lead to preventative or curative therapies.

Conditions

Atrial Fibrillation

Keywords

atrial fibrillation; genetics; genetic polymorphisms

Study Arms (2)

1

Patients of the Cardiovascular Institute with known cardiac conditions and no history of atrial fibrillation.

2

Patients of the Cardiovascular Institute with known cardiac conditions and a history of atrial fibrillation.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects must be patients of the UPMC Cardiovascular Institute who are under the medical care of UPMC cardiologists.

You may qualify if:

• + years of age
• Able to give informed consent

You may not qualify if:

• Inability to provide informed consent

Sponsors & Collaborators

• University of Pittsburgh: lead
• EP Research funds: collaborator

Study Sites (1)

University of Pittsburgh Medical Center/Comprehensive Heart Ctr.

Pittsburgh, Pennsylvania, 15213, United States

Location

Related Publications (3)

• Gensini F, Padeletti L, Fatini C, Sticchi E, Gensini GF, Michelucci A. Angiotensin-converting enzyme and endothelial nitric oxide synthase polymorphisms in patients with atrial fibrillation. Pacing Clin Electrophysiol. 2003 Jan;26(1P2):295-8. doi: 10.1046/j.1460-9592.2003.00036.x.

  PMID: 12687832 BACKGROUND

• Lai LP, Lin JL, Lin CS, Yeh HM, Tsay YG, Lee CF, Lee HH, Chang ZF, Hwang JJ, Su MJ, Tseng YZ, Huang SK. Functional genomic study on atrial fibrillation using cDNA microarray and two-dimensional protein electrophoresis techniques and identification of the myosin regulatory light chain isoform reprogramming in atrial fibrillation. J Cardiovasc Electrophysiol. 2004 Feb;15(2):214-23. doi: 10.1046/j.1540-8167.2004.03423.x.

  PMID: 15028053 BACKGROUND

• Gaudino M, Andreotti F, Zamparelli R, Di Castelnuovo A, Nasso G, Burzotta F, Iacoviello L, Donati MB, Schiavello R, Maseri A, Possati G. The -174G/C interleukin-6 polymorphism influences postoperative interleukin-6 levels and postoperative atrial fibrillation. Is atrial fibrillation an inflammatory complication? Circulation. 2003 Sep 9;108 Suppl 1:II195-9. doi: 10.1161/01.cir.0000087441.48566.0d.

  PMID: 12970232 BACKGROUND

MeSH Terms

Conditions

Atrial Fibrillation

Condition Hierarchy (Ancestors)

Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• David S. Schwartzman, MD

  University of Pittsburgh/UPMC

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 2, 2005
• First Posted: November 3, 2005
• Study Start: January 1, 2005
• Primary Completion: January 1, 2010
• Study Completion: January 1, 2010
• Last Updated: January 5, 2016

Record last verified: 2016-01

Locations

US (1)