Prevalence of Delirium in Patients Undergoing Cardiac Surgery

NCT00242151 | Unknown

• 1 other identifier: UHN REB 05-0223-AE
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this study is to determine prevalence of postoperative delirium and confusion in patients undergoing cardiac surgery. This proposal is a pilot study designed to evaluate effect of cardiac surgery on prevalence of delirium and confusion. The primary aim is to evaluate prevalence of delirium and confusion in patients undergoing cardiac surgery and to determine risk factors for this condition. A secondary aim is to evaluate organic brain injury by early postoperative diffusion weighted magnetic resonance imaging (DW-MRI) in patients who develop delirium and confusion. The hypothesis to be tested is that patients with postoperative delirium and confusion have high incidence of organic brain injury as detected by DW-MRI.

Conditions

Heart Disease

Keywords

Delirium, Confusion, Cardiac Surgery, Organic Brain Injury, Diffusion Weighted Magnetic Resonance Imaging (DW-MRI)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• All patients undergoing cardiac surgery in our institute in 2 year period
• Signed informed consent

You may not qualify if:

• Past history of transient ischemic attacks, stroke, symptomatic carotid artery disease.
• Past history of psychiatric disorders
• History of alcohol and drug abuse
• History of severe kidney or liver disease (creatinine \>2.5mg/dL and bilirubin \> 2mg/dL)
• Known contraindications to MRI

Sponsors & Collaborators

• University Health Network, Toronto: lead

Study Sites (1)

Toronto General Hospital, University Health Network

Toronto, Ontario, M5G 2C4, Canada

RECRUITING

MeSH Terms

Conditions

Heart Diseases; Delirium; Confusion

Condition Hierarchy (Ancestors)

Cardiovascular Diseases; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurocognitive Disorders; Mental Disorders

Study Officials

• Rita Katznelson, MD

  Toronto General Hospital, University Health Network

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jo A Carroll, RN

CONTACT

416-340-4800; jo.carroll@uhn.on.ca

Study Design

• Study Type: observational
• Observational Model: DEFINED POPULATION
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: October 18, 2005
• First Posted: October 19, 2005
• Last Updated: October 12, 2006

Record last verified: 2006-09

Locations

CA (1)