Genetics of Interstitial Cystitis

NCT00237081 | Completed

• 1 other identifier: DK66136-MaGIC (completed)
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The cause of interstitial cystitis is unknown. However, it tends to run in some families suggesting that there may be a genetic susceptibility to the disease. For instance, the disease is found 17 times more commonly in first-degree relatives (parent, sibling, or child) of patients with interstitial cystitis than in the general population. Furthermore, if one twin has interstitial cystitis, the disease is much more common in identical co-twins than fraternal co-twins. This evidence suggests that, in some families, genes that make a person susceptible to interstitial cystitis are being passed from one generation to the next. The University of Maryland School of Medicine and the National Institutes of Health are performing a study to identify these genes for susceptibility for interstitial cystitis. This study is entitled the Maryland Genetics of Interstitial Cystitis (MaGIC) study. The MaGIC study will investigate several hundred families with two or more blood relatives with interstitial cystitis. The study will seek to find changes in genes that are found far more commonly in family members who have interstitial cystitis than in those who do not have the disease.Identifying these genes should lead to a better understanding of the cause of interstitial cystitis. Finding the cause is the first step to finding the cure. This is a national study which is conducted by telephone and mail, and in which you can participate entirely from your home.

Conditions

Interstitial Cystitis; Painful Bladder Syndrome

Keywords

Interstitial Cystitis; Painful Bladder Syndrome; Genetics; Risk factors; Family history

Eligibility Criteria

• Age: 13 Years+
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Have interstitial cystitis, or painful bladder syndrome.
• Have at least one blood relative with interstitial cystitis, painful bladder syndrome, or urinary symptoms similar to yours.
• Are 13 years of age or older.
• Are available for a telephone, mail, or website interview.
• Live in the USA or Canada.

You may not qualify if:

• Are less than 13 years of age.
• Have Parkinson's disease, Multiple Sclerosis, Spina bifida, or another neurologic disease that preceeded your interstitial cystitis symptoms

Sponsors & Collaborators

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): lead

Study Sites (1)

University of Maryland Interstitial Cystitis Center

Baltimore, Maryland, 21201, United States

Location

Related Links

• Interstitial Cystitis Association
• Interstitial Cystitis Network

MeSH Terms

Conditions

Cystitis, Interstitial

Condition Hierarchy (Ancestors)

Cystitis; Urinary Bladder Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• John W Warren, M.D.

  University of Maryland, College Park

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: OTHER
• Sponsor Type: NIH

Study Record Dates

• First Submitted: October 11, 2005
• First Posted: October 12, 2005
• Study Start: June 1, 2004
• Study Completion: November 1, 2008
• Last Updated: March 17, 2020

Record last verified: 2010-03

Locations

US (1)