Effect of Positive Expiratory Pressure on Right Ventricular Function in Patients With Respiratory Distress Syndrome

NCT00236262 | Completed DMC

• 2 other identifiers: P040202PS040202
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of this study is to analyze by trans-oesophageal echocardiography the effect on the right ventricle of positive expiratory pressure (PEP) level variations with constant plate pressure among patients with syndrome of acute respiratory distress of the adult (SDRA). The assumption tested is that a high level of PEP increases the impedance with the ejection of the right ventricle independently of the level of plate pressure. The effect on the right ventricular preload will be checked via the analysis of the respiratory variability of the diameter of the higher vena cava.

Conditions

Respiratory Distress Syndrome, Adult

Keywords

SDRA; Distress; Expiratory; Pressure; Ventilatory

Outcome Measures

Primary Outcomes (2)

• Safety

• Efficacy

Interventions

ventilatory strategies with pressure DEVICE

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Intubation and artificial ventilation
• Bilateral pulmonary opacities radiological compatible with an organic pulmonary oedema
• PaO2/FiO2 report/ratio \< 200 mmHg
• Not obviously clinical or echocardiographic of rise in the pressure of ventricular filling left
• Joint presence of criteria 2, 3 and 4 since less than 72 hours

You may not qualify if:

• Age \<18 years
• Pregnancy
• Obstructive chronic broncho-pneumonopathy
• Suspected or confirmed intracranial hypertension
• Pneumothorax
• Evolutionary oesophageal pathology
• PaO2/FiO2 Report/ratio \< 50 mmHg
• Amount of adrenaline or noradrenaline higher than 2 mg/hour

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

HOPITAL HENRI MONDOR Department of Neurosurgery

Créteil, 94010, France

Location

Related Publications (3)

• Bouadma L, Lellouche F, Cabello B, Taille S, Mancebo J, Dojat M, Brochard L. Computer-driven management of prolonged mechanical ventilation and weaning: a pilot study. Intensive Care Med. 2005 Oct;31(10):1446-50. doi: 10.1007/s00134-005-2766-2. Epub 2005 Aug 23.

  PMID: 16132889 BACKGROUND

• Lacherade JC, Auburtin M, Cerf C, Van de Louw A, Soufir L, Rebufat Y, Rezaiguia S, Ricard JD, Lellouche F, Brun-Buisson C, Brochard L. Impact of humidification systems on ventilator-associated pneumonia: a randomized multicenter trial. Am J Respir Crit Care Med. 2005 Nov 15;172(10):1276-82. doi: 10.1164/rccm.200408-1028OC. Epub 2005 Aug 26.

  PMID: 16126933 BACKGROUND

• Mekontso Dessap A, Charron C, Devaquet J, Aboab J, Jardin F, Brochard L, Vieillard-Baron A. Impact of acute hypercapnia and augmented positive end-expiratory pressure on right ventricle function in severe acute respiratory distress syndrome. Intensive Care Med. 2009 Nov;35(11):1850-8. doi: 10.1007/s00134-009-1569-2. Epub 2009 Aug 4.

  PMID: 19652953 DERIVED

MeSH Terms

Conditions

Respiratory Distress Syndrome

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiration Disorders

Study Officials

• Laurent BROCHARD, Pr,MD,PhD

  Assistance Publique - Hôpitaux de Paris

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: October 7, 2005
• First Posted: October 12, 2005
• Study Start: October 1, 2005
• Study Completion: September 1, 2006
• Last Updated: March 26, 2007

Record last verified: 2007-03

Locations

FR (1)