NCT00235378|Completed
Genetic Study of Lupus Patients and Their Families
Gene Mapping in Women With SLE
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Gene Mapping in Women With SLE
Sponsor study identifier
NIH
Secondary identifiers
NIH
observational
2,356
1 country
1
Study Start
July 1996
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
March 2013
Actual (reported)Study Completion
March 2013
Actual (reported)The purpose of this study is to perform genetic testing in and to collect information from families affected by lupus in order to identify the genetic factors associated with systemic lupus erythematosus (SLE).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 2013
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 1996
Date type not reportedThis date has not been verified as actual or estimated.
October 6, 2005
Actual (reported)October 10, 2005
Actual (reported)March 2013
Actual (reported)March 2013
Actual (reported)SLE patients
Unaffected family members of SLE patients
Control participants
Participants include SLE patients, their unaffected family members, and healthy controls.
University of Minnesota
Minneapolis, Minnesota, 55455, United States
Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ, Shark KB, Grande WJ, Hughes KM, Kapur V, Gregersen PK, Behrens TW. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2610-5. doi: 10.1073/pnas.0337679100. Epub 2003 Feb 25.
Gillett CD, Langefeld CD, Williams AH, Ortmann WA, Graham RR, Rodine PR, Selby SA, Gaffney PM, Behrens TW, Moser KL. Fine mapping chromosome 16q12 in a collection of 231 systemic lupus erythematosus sibpair and multiplex families. Genes Immun. 2005 Feb;6(1):19-23. doi: 10.1038/sj.gene.6364145.
Blood
Timothy W. Behrens, MD
University of Minnesota
Patrick Gaffney
University of Minnesota
2,356 participants (actual enrollment reported by the registry).
First Submitted
October 6, 2005
First Posted
October 10, 2005
Study Start
July 1996
Date type not reportedThis date has not been verified as actual or estimated.
Hormonal and Environmental Risk Factors for Developing Systemic Lupus Erythematosus: The Carolina Lupus (CLU) Study
Contact the study team to confirm eligibility.
Graham RR, Ortmann WA, Langefeld CD, Jawaheer D, Selby SA, Rodine PR, Baechler EC, Rohlf KE, Shark KB, Espe KJ, Green LE, Nair RP, Stuart PE, Elder JT, King RA, Moser KL, Gaffney PM, Bugawan TL, Erlich HA, Rich SS, Gregersen PK, Behrens TW. Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. Am J Hum Genet. 2002 Sep;71(3):543-53. doi: 10.1086/342290. Epub 2002 Jul 26.
Kyogoku C, Langefeld CD, Ortmann WA, Lee A, Selby S, Carlton VE, Chang M, Ramos P, Baechler EC, Batliwalla FM, Novitzke J, Williams AH, Gillett C, Rodine P, Graham RR, Ardlie KG, Gaffney PM, Moser KL, Petri M, Begovich AB, Gregersen PK, Behrens TW. Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE. Am J Hum Genet. 2004 Sep;75(3):504-7. doi: 10.1086/423790. Epub 2004 Jul 23.
Wakeland EK, Liu K, Graham RR, Behrens TW. Delineating the genetic basis of systemic lupus erythematosus. Immunity. 2001 Sep;15(3):397-408. doi: 10.1016/s1074-7613(01)00201-1.
Primary Completion
March 2013
Actual (reported)Study Completion
March 2013
Actual (reported)Last Updated
October 15, 2015
Record last verified: 2015-10
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Source: ClinicalTrials.gov.
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