NCT00231972

Brief Summary

This study will evaluate the effectiveness of a behavioral intervention program versus standard prevention case management in promoting safer sex practices in HIV-infected men.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
201

participants targeted

Target at P50-P75 for not_applicable hiv-infections

Timeline
Completed

Started Dec 2003

Longer than P75 for not_applicable hiv-infections

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2003

Completed
1.8 years until next milestone

First Submitted

Initial submission to the registry

September 30, 2005

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 4, 2005

Completed
2.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2008

Completed
Last Updated

April 8, 2011

Status Verified

February 1, 2011

Enrollment Period

4.6 years

First QC Date

September 30, 2005

Last Update Submit

April 7, 2011

Conditions

Keywords

HIVMSM

Outcome Measures

Primary Outcomes (1)

  • Reduction in rates of unprotected anal intercourse from baseline to 12-month follow-up

    Measured at Months 3, 6, 9, and 12

Secondary Outcomes (4)

  • Incidence of sexually transmitted diseases

    Measured at Months 3, 6, 9, and 12

  • Higher risk-reduction self-efficacy

    Measured at Months 3, 6, 9, and 12

  • Increased behavioral intentions to engage in safer behaviors

    Measured at Months 3, 6, 9, and 12

  • Increased risk-reduction strategies (other than condom use)

    Measured at Months 3, 6, 9, and 12

Study Arms (2)

Project Enhance

EXPERIMENTAL

Participants will receive the risk reduction program, Project Enhance

Behavioral: Project Enhance

Active Comparison Condition

ACTIVE COMPARATOR

Participants will receive standard prevention case management

Behavioral: Standard prevention case management (PCM)

Interventions

Project EnhanceBEHAVIORAL

The behavioral intervention will be administered by a trained medical social worker on an individual basis. It will include an education component, as well as motivational and behavioral skills enhancement. Treatment will occur for only the first 3 months, after which follow-up sessions will be held every 3 months for the remainder of the year.

Also known as: Project Enhance Behavioral Intervention
Project Enhance

Participants will receive standard PCM for HIV prevention.

Also known as: Project Enhance Prevention Case Management
Active Comparison Condition

Eligibility Criteria

Age18 Years+
Sexmale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • HIV infected
  • Receives primary health care at Fenway Community Health
  • Identifies as a man who has sex with men
  • Has engaged in unprotected anal or vaginal intercourse within 3 months of study enrollment

You may not qualify if:

  • All episodes of unprotected anal intercourse occurred with only a single primary partner who is also HIV infected
  • Plans to relocate over the upcoming year

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Fenway Community Health

Boston, Massachusetts, 02115, United States

Location

MeSH Terms

Conditions

HIV Infections

Condition Hierarchy (Ancestors)

Blood-Borne InfectionsCommunicable DiseasesInfectionsSexually Transmitted Diseases, ViralSexually Transmitted DiseasesLentivirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesGenital DiseasesUrogenital DiseasesImmunologic Deficiency SyndromesImmune System Diseases

Study Officials

  • Kenneth Mayer, MD

    Fenway Community Health and Brown University

    PRINCIPAL INVESTIGATOR
  • Steven Safren, PhD

    Fenway Community Health and Harvard Medical School

    PRINCIPAL INVESTIGATOR
  • Conall O'Cleirigh, PhD

    Fenway Community Health and Massachusetts General Hospital

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

September 30, 2005

First Posted

October 4, 2005

Study Start

December 1, 2003

Primary Completion

July 1, 2008

Study Completion

July 1, 2008

Last Updated

April 8, 2011

Record last verified: 2011-02

Locations