A Pilot Study to Develop a Technique for External Beam Radiotherapy After Radical Prostatectomy Based on MRI-Delineation of the Clinical Target Volume
Sponsor study identifier
interventional
27
1 country
1
Study Start
January 2005
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
May 2013
Actual (reported)Study Completion
May 2013
Actual (reported)Delivery of conformal radiation therapy following radical prostatectomy is limited by the inability to define the clinical target volume (CTV). This stems from a poor understanding of patterns of local recurrence and limitations of standard imaging techniques.Magnetic Resonance Imaging (MRI) is a promising modality for imaging the prostatic bed following radical prostatectomy. MRI provides more detailed postoperative anatomy to guide CTV delineation, the ability to document local recurrence patterns, and a method to assess intrafraction prostatic bed motion and deformity to define appropriate planning target volume margins. The aim of this pilot study is to develop a technique for external beam radiation therapy (EBRT) following radical prostatectomy based on MRI-delineation of the CTV. Twenty patients will be enrolled in this pilot, development phase.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 2013
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 2005
Date type not reportedThis date has not been verified as actual or estimated.
September 28, 2005
Actual (reported)September 30, 2005
Actual (reported)May 2013
Actual (reported)May 2013
Actual (reported)To develop a technique for MRI-delineation of the clinical target volume (CTV) for EBRT following radical prostatectomy
After data acquisition
To compare the reproducibility of clinical target volume and rectal wall volume delineation on MRI and CT.
After data acquisition
To compare the location of the urethral anastomosis defined on MRI as compared to a fiducial marker placed under TRUS-guidance adjacent to the anastomosis.
After data acquisition
To measure the amount of intrafraction movement and deformity of the prostatic bed and seminal vesicles with current bowel regimen of daily milk of magnesia using cinematic MRI.
After data acquisition
To determine the optimal radiation technique that encompasses the MRI-defined PTV whilst respecting bowel and bladder dose constraints.
After data acquisition
To measure the amount of interfraction movement and deformity of the bladder, rectum, and surgical clips within the operative bed using daily cone-beam CT imaging.
After data acquisition
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Princess Margaret Hospital
Toronto, Ontario, M5G 2M9, Canada
Cynthia Menard, MD
Princess Margaret Hospital, Canada
27 participants (actual enrollment reported by the registry).
First Submitted
September 28, 2005
First Posted
September 30, 2005
Study Start
January 2005
Date type not reportedThis date has not been verified as actual or estimated.
Transrectal Tumour Oxygen - US Army
Contact the study team to confirm eligibility.
Primary Completion
May 2013
Actual (reported)Study Completion
May 2013
Actual (reported)Last Updated
January 6, 2014
Record last verified: 2014-01
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Source: ClinicalTrials.gov.
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