NCT00223470

Brief Summary

This clinical trial evaluates the role of cytokines in patients needing root canal treatment with diagnosis of necrotic pulp and chronic apical periodontitis

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
9

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Oct 2002

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2002

Completed
3 years until next milestone

First Submitted

Initial submission to the registry

September 13, 2005

Completed
9 days until next milestone

First Posted

Study publicly available on registry

September 22, 2005

Completed
2.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2008

Completed
Last Updated

March 9, 2012

Status Verified

March 1, 2012

Enrollment Period

5.7 years

First QC Date

September 13, 2005

Last Update Submit

March 7, 2012

Conditions

Chronic Apical Periodontitis of Pulpal Origin

Keywords

pain

Eligibility Criteria

Age16 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Patients presenting to the Endodontics department with an indication for root canal treatment

You may qualify if:

  • Patient must be at least 16 years of age.
  • Clinical indication for Non-Surgical Root Canal Therapy (NSRCT).
  • st or 2nd maxillary or mandibular molar
  • Diagnosis must be Chronic Apical Periodontitis (CAP) with or without symptoms.
  • Intact, mature apices.
  • ASA I or II

You may not qualify if:

  • Failure to meet any of the above
  • Previous NSRCT
  • Previous pulpotomy or pulpectomy
  • Suppurative apical periodontitis
  • Patients taking medications which can affect their pain rating or medications which effect their immune system ( such as glucocorticoids)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Univerity of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Sterile paper points are placed in the canal for 30 seconds

MeSH Terms

Conditions

Pain

Condition Hierarchy (Ancestors)

Neurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Asma A Khan, BDS, PhD

    The University of Texas Health Science Center at San Antonio

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 13, 2005

First Posted

September 22, 2005

Study Start

October 1, 2002

Primary Completion

June 1, 2008

Study Completion

June 1, 2008

Last Updated

March 9, 2012

Record last verified: 2012-03

Locations

US(1)