NCT00222937

Brief Summary

The study compares two different forms of voice therapy, Lessac-Madsen Resonant Voice Therapy and Casper-Based Confidential Flow Therapy. The target population are teachers because they have the highest risk for developing voice problems. For this study the investigators are primarily interested in seeing if Lessac-Madsen Resonant Voice Therapy (LMRVT) and Casper-Based Confidential Flow Therapy (CBCFT) are equally effective at improving vocal functioning in teachers with phonotrauma, as assessed by the Voice Handicap Index (VHI).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
105

participants targeted

Target at P25-P50 for phase_3

Timeline
Completed

Started Oct 2005

Longer than P75 for phase_3

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 20, 2005

Completed
2 days until next milestone

First Posted

Study publicly available on registry

September 22, 2005

Completed
9 days until next milestone

Study Start

First participant enrolled

October 1, 2005

Completed
3.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2009

Completed
1.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2010

Completed
Last Updated

January 25, 2016

Status Verified

January 1, 2016

Enrollment Period

3.7 years

First QC Date

September 20, 2005

Last Update Submit

January 21, 2016

Conditions

Keywords

Voice ProblemsVoice Disorders

Outcome Measures

Primary Outcomes (1)

  • Score on Voice Handicap Index (VHI)

    one year

Secondary Outcomes (5)

  • Does LMRVT contribute to the actual acquisition of "resonant voice" in speech?

    one year

  • Do LMRVT or CBCFT improve laryngeal appearance?

    one year

  • Do LMRVT or CBCFT improve conversational voice quality?

    one year

  • Do LMRVT or CBCFT reduce the occurrence of laryngeal microsurgery?

    one year

  • Do LMRVT or CBCFT reduce the number of workdays lost annually?

    one year

Study Arms (2)

A

EXPERIMENTAL

Patients are enrolled in Lessac-Madsen Resonant Voice Therapy.

Behavioral: Lessac-Madsen Resonant Voice Therapy

B

EXPERIMENTAL

Patients are enrolled in Casper Based Confidential Flow Therapy.

Behavioral: Casper-Based Confidential Flow Therapy

Interventions

Patients receive 8 sessions of therapy over a course of 4 weeks, with one double session per week.

A

Patients receive 8 sessions of therapy over a course of 4 weeks, with one double session per week.

B

Eligibility Criteria

Age21 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Full or part time teacher including college professor, daycare and preschool
  • years of age and older
  • Complaints of voice problems declared to be lasting continuously for one month or more
  • Any structural or functional change to the larynx that appears related to phonation,including bilateral or unilateral lesions (assuming normal overlying epithelium based on clinical examination), non-specific edema, or erythema that appear by clinical history related to phonation, or primary muscle tension dysphonia or other condition related to phonation without lesions
  • No concurrent ear, nose and/or throat diagnoses, e.g. acute allergies, except for chronic allergies, sinusitis, and laryngopharyngeal reflux disease (LPR)
  • No vocal fold hemorrhage
  • No known degenerative medical conditions (e.g., degenerative neuromuscular disease, malignant process undergoing treatment or with less than 5 years remission, uncontrolled systemic disease (e.g., auto immune disease, or hormonal condition)
  • Normal hearing to 30 dB at 1000Hz - 3000Hz in the better ear
  • The participant is able to start therapy within 6 weeks of the initial evaluation and can be scheduled for 8 sessions (two per visit) in a 6-week time period
  • Agreement by the participant to provide information regarding days missed from work during the previous year and the year following treatment

You may not qualify if:

  • Known degenerative medical condition
  • Degenerative medical conditions that would exclude a participant from participation include, but are not limited to: degenerative neuromuscular disease, malignant process undergoing treatment or with less than 5 years remission, uncontrolled systemic disease (e.g. auto immune disease), or hormonal condition.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Massachusetts Eye & Ear Infirmary, Voice and Speech Laboratory

Boston, Massachusetts, 02114, United States

Location

University of Pittsburgh Medical Center, Voice Center

Pittsburgh, Pennsylvania, 15219, United States

Location

MeSH Terms

Conditions

Voice Disorders

Condition Hierarchy (Ancestors)

Laryngeal DiseasesRespiratory Tract DiseasesOtorhinolaryngologic DiseasesNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Katherine Verdolini, Ph.D.

    University of Pittsburgh

    PRINCIPAL INVESTIGATOR
  • Clark Rosen, M.D.

    University of Pittsburgh

    STUDY DIRECTOR
  • Jackie Gartner-Schmidt, Ph.D.

    University of Pittsburgh

    STUDY DIRECTOR
  • Franca Benedicty Barton, M.S.

    The Emmes Company, LLC

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

September 20, 2005

First Posted

September 22, 2005

Study Start

October 1, 2005

Primary Completion

June 1, 2009

Study Completion

August 1, 2010

Last Updated

January 25, 2016

Record last verified: 2016-01

Locations