NCT00213551|CompletedPhase 1
Glutamine and Intestinal Protein Metabolism
Comparative Effects of Glutamine and Glucose on Intestinal Protein Metabolism in Healthy Humans
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Comparative Effects of Glutamine and Glucose on Intestinal Protein Metabolism in Healthy Humans
Sponsor study identifier
interventional
30
1 country
1
Study Start
April 2004
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
June 2008
Actual (reported)Gut barrier plays a major role in defence of the organism. During catabolic states, like major surgery or inflammation, gut barrier could be altered. It has been reported that preoperative nutritional support may have beneficial effects on clinical outcome in patients with surgery on gastrointestinal tract. Glutamine, which is a conditionally essential amino, have been reported to modulate inflammatory, antioxidant responses and protein metabolism in intestine. In addition, glutamine supply improves clinical outcome in critically ill patients. Antioxidant micronutrients may also have some beneficial effects in intestine by improving antioxidant response and might also regulate protein expression. Nevertheless, effects of glutamine combined to antioxidant micronutrients have not been evaluated. Thus, the aim of this study will be to assess the influence of glutamine and glutamine-antioxidant micronutrients-containing solutions on intestinal response in humans.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2008
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 2004
Date type not reportedThis date has not been verified as actual or estimated.
September 13, 2005
Actual (reported)September 21, 2005
Actual (reported)June 2008
Actual (reported)Impact on protein synthesis rate and proteolytic activities in intestine.
at the end of infusion (hour 5)
Comparison of protein expression pattern and glutathione synthesis.
at the end of infusion (hour 5)
University Hospital of Rouen
Rouen, 76031, France
Goichon A, Coeffier M, Claeyssens S, Lecleire S, Cailleux AF, Bole-Feysot C, Chan P, Donnadieu N, Lerebours E, Lavoinne A, Boyer O, Vaudry D, Dechelotte P. Effects of an enteral glucose supply on protein synthesis, proteolytic pathways, and proteome in human duodenal mucosa. Am J Clin Nutr. 2011 Sep;94(3):784-94. doi: 10.3945/ajcn.110.009738. Epub 2011 Jul 27.
Pierre Déchelotte, MD, PhD
University Hospital, Rouen
First Submitted
September 13, 2005
First Posted
September 21, 2005
Study Start
April 2004
Date type not reportedThis date has not been verified as actual or estimated.
Study Completion
June 2008
Actual (reported)Contact the study team to confirm eligibility.
Last Updated
June 18, 2013
Record last verified: 2013-06
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Source: ClinicalTrials.gov.
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