NCT00211822

Terminated

Functional Magnetic Resonance Imaging (fMRI) Studies in Path...

Icahn School of Medicine at Mount Sinai Source

Icahn School of Medicine at Mount Sinai

ClinicalTrials.gov

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Other study identifiers

Sponsor study identifier

GCO#04-1034

Study Type

observational

Actual enrollment (reported)

57

Locations

1 country

Sites

1

Timeline

Study Start

November 2004

Date type not reported

This date has not been verified as actual or estimated.

Primary Completion

December 2010

Actual (reported)

Study Completion

December 2010

Actual (reported)

Brief Summary

This study will explore the brain processes associated with inhibition and reward processing in pathological gamblers and people with obsessive compulsive disorder compared to healthy controls.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: terminated
Actual enrollment (reported): 57 participants
Study completion date: December 2010
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Some registry-reported names shown below are not yet linked in this graph.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

Study Start
November 2004
Date type not reported
This date has not been verified as actual or estimated.
First Submitted
September 13, 2005
Actual (reported)
First Posted
September 21, 2005
Actual (reported)
Primary Completion
December 2010
Actual (reported)
Study Completion
December 2010
Actual (reported)

Last Updated: July 14, 2011
Status Verified: July 2011
Last Update Submitted: July 13, 2011

Conditions

Obsessive Compulsive Disorder Pathological Gambling

Keywords

Pathological GamblingObsessive-Compulsive DisorderGo No-goMonetary incentives delayfMRI

Outcome Measures

Primary Outcomes (2)

fMRI - go-nogo task
a measure of behavioral response inhibition
at baseline
fMRI - monetary incentive delay (MID) task
a measure of neural response to anticipating and receiving monetary rewards
at baseline

Study Arms (3)

Pathologic Gamblers

Procedure: fMRI

Obsessive Compulsive Disorder

Procedure: fMRI

Healthy Controls

Procedure: fMRI

Interventions

fMRIProcedure

fMRI

Healthy ControlsObsessive Compulsive DisorderPathologic Gamblers

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 55 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64)

Sampling MethodNon-Probability Sample

Study Population

community sample

You may qualify if:

Male or female adults diagnosed with pathological gambling or obsessive compulsive disorder aged 18-55.

Sponsors & Collaborators

Icahn School of Medicine at Mount Sinai
Otherlead
Abbott
Industrycollaborator

Study Sites (1)

Mount Sinai School of Medicine

New York, New York, 10029, United States

MeSH Terms

Conditions

GamblingObsessive-Compulsive Disorder

Condition Hierarchy (Ancestors)

Risk-TakingBehaviorDisruptive, Impulse Control, and Conduct DisordersMental DisordersAnxiety Disorders

Study Officials

Eric Hollander, MD
Icahn School of Medicine at Mount Sinai
PRINCIPAL INVESTIGATOR

Enrollment

57 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: CROSS SECTIONAL
Sponsor Type: OTHER

Study Record Dates

First Submitted

September 13, 2005

First Posted

September 21, 2005

Study Start

November 2004

Date type not reported

This date has not been verified as actual or estimated.

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Phase 1/2Completed

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Phase 3Completed

Subject has signed an informed consent form

Must provide contact information

Must be in generally good health

Must be willing and able to read written instructions and complete scales

Must be English speaking

In the opinion of the investigator, the subject is capable of complying with all study procedures

Pathological Gamblers only:

Current diagnosis of pathological gambling, supported by DSM-IV SCI-PG

Must score ≥ 5 on SOGS

Must score ≥ 2 on item number 1 on the G-SAS

Subjects must have a severity score of ≥ 4 (moderately ill) on the Clinical Global Impressions Scale - Severity (CGI-S)

Must score ≥ 10 on questions 1-5 on PG-Y-BOCS

Must score ≤ 15 on YMRS

Must have gambled once within past 2 weeks of Screening Visit.

You may not qualify if:

Subjects with a primary diagnosis of schizophrenia, personality disorder, or other psychotic disorders
Subjects with a primary diagnosis of an Axis I disorder that may require intervention
Must not score \>24 on the Montgomery-Asberg Depression Rating Scale (MADRS) (pathological gamblers only)
Subjects who live in a restrictive environment
Subjects with a current DSM-IV diagnosis of substance dependence or abuse, excluding nicotine
Subjects reporting a history of drug and/or alcohol dependence or abuse; subjects who report occasional drug use in the past will be discussed by a panel (consisting of Dr. Gilbert, Dr. Fan and Dr. Bartz), and will be considered for participation on a case by case basis
Subjects who have used psychotropic medications in the past week to six weeks (depending on the medication)
Subject has a positive drug urine screen
Female subjects who are pregnant
Subjects who report a history of severe liver, heart, or kidney disease because these conditions are associated with neurological sequella
Employees of the investigator or study center or their families
Finally, subjects who do not satisfy the following criteria will be excluded because they will be unable to undergo the MRI procedure. Specifically, subjects will be excluded who have:
a pacemaker
any implanted metallic chips in their head
ever worked around a metal lathe or had a shrapnel (war or gun shot) wound/injury
+11 more criteria

Contact the study team to confirm eligibility.

Primary Completion

December 2010

Actual (reported)

Study Completion

December 2010

Actual (reported)

Last Updated

July 14, 2011

Record last verified: 2011-07

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT00211822
Data provider: ClinicalTrials.gov
Source updated: 2011-07-14
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:39:39 UTC

Locations

US(1)

Study Stopped

Functional Magnetic Resonance Imaging (fMRI) Studies in Pathological Gambling (PG) and Obsessive-Compulsive Disorder (OCD)

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Study Arms (3)

Pathologic Gamblers

Obsessive Compulsive Disorder

Healthy Controls

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Study Arms (3)

Pathologic Gamblers

Obsessive Compulsive Disorder

Healthy Controls

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations