NCT00190372

Brief Summary

The aim of the project is to demonstrate that a psycho-educational programme designed to support and train carers of Alzheimer's disease (AD) patients induces a significantly higher benefit than anticholinesterase drug treatment alone or associated to memantine treatment. This training programme focuses on the explanation/description of behavioral, cognitive and functional disorders induced by the disease, as well as principles of cognitive and psycho-social stimulation of the patients in daily life.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
240

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Oct 2004

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2004

Completed
12 months until next milestone

First Submitted

Initial submission to the registry

September 14, 2005

Completed
5 days until next milestone

First Posted

Study publicly available on registry

September 19, 2005

Completed
2.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2008

Completed
Last Updated

February 17, 2011

Status Verified

March 1, 2007

Enrollment Period

3.6 years

First QC Date

September 14, 2005

Last Update Submit

February 16, 2011

Conditions

Keywords

Alzheimer's disease training programmeeducational programme caregivers carers dementia treatmentDementia Cognitive disorder

Outcome Measures

Primary Outcomes (1)

  • DAD scale (Disability Assessment for Dementia)

    at 6 months

Secondary Outcomes (6)

  • cardiovascular mortality

    at 6 months

  • functional status

    at 4 weeks

  • for the patient: NPI and ADAS-Cog

    during the study

  • for the caregiver: ZARIT scale, questionnaire of feeling of competency, Montgomery and Asberg Depression Rating Scale (MADRS), Geriatric Depression Scale (GDS)

    during the study

  • all cause mortality

    at one year

  • +1 more secondary outcomes

Study Arms (1)

A

OTHER
Behavioral: Controlled dietBehavioral: Self-hypnotic relaxation

Interventions

Controlled dietBEHAVIORAL

Controlled diet

A

Self-hypnotic relaxation

A

Eligibility Criteria

Age60 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients:
  • AD outpatients
  • Stable pharmacological treatment
  • Mini-Mental State Examination (MMSE) \[10 -28\]
  • Age \[60-90\]
  • Informed consent
  • Caregivers:
  • Reliability
  • Motivation
  • Psychological disorder related to patient's disease
  • Need for information or help
  • Informed consent

You may not qualify if:

  • Patients:
  • Other dementia
  • Severe general disease
  • No reliable caregiver
  • Caregivers:
  • Physical or mental disease incompatible with patient's management
  • Impossibility to participate in the educational program
  • Absence of anxiety-depression
  • Psychotherapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Assistance Publique-Hôpitaux de Paris

Paris, Île-de-France Region, 75010, France

Location

Related Publications (1)

  • Wenisch E, Stoker A, Bourrellis C, Pasquet C, Gauthier E, Corcos E, Banchi MT, De Rotrou J, Rigaud AS. [A global intervention program for institutionalized demented patients]. Rev Neurol (Paris). 2005 Mar;161(3):290-8. doi: 10.1016/s0035-3787(05)85035-0. French.

    PMID: 15800450BACKGROUND

MeSH Terms

Conditions

Alzheimer Disease

Condition Hierarchy (Ancestors)

DementiaBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesTauopathiesNeurodegenerative DiseasesNeurocognitive DisordersMental Disorders

Study Officials

  • Anne-Sophie Rigaud, Pr, MD, PhD

    Assistance Publique - Hôpitaux de Paris

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
CARE PROVIDER
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

September 14, 2005

First Posted

September 19, 2005

Study Start

October 1, 2004

Primary Completion

May 1, 2008

Study Completion

May 1, 2008

Last Updated

February 17, 2011

Record last verified: 2007-03

Locations