NCT00188981

Brief Summary

The Dutch Prediction of Psychosis Study (DUPS) is a prospective study of predictors of the transition to psychosis in help-seeking adolescents at high risk for developing a first psychotic episode. The aim of the project is supplemented by a systematic account of the pathways to care, the disabilities and needs and the therapeutic interventions that are currently used in this population. Multi-level assessment includes behavioral and cognitive variables as well as structural brain imaging and neurophysiological data. Subjects will be followed up at regular intervals during (at least) two years to monitor the development of their (psychotic) symptoms. This will allow us to analyze the predictive validity of the variables.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
120

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Jun 2003

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2003

Completed
2.3 years until next milestone

First Submitted

Initial submission to the registry

September 9, 2005

Completed
7 days until next milestone

First Posted

Study publicly available on registry

September 16, 2005

Completed
2.7 years until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2008

Completed
Last Updated

April 20, 2007

Status Verified

April 1, 2007

First QC Date

September 9, 2005

Last Update Submit

April 19, 2007

Conditions

Psychotic Disorders

Keywords

psychosishigh riskprodromeMultiple Complex Developmental Disorder

Eligibility Criteria

Age12 Years - 18 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Help-seeking adolescents who belong to one or more of the following groups:
  • Basic symptoms: presence of self-perceived cognitive thought disturbances
  • Familial risk plus reduced functioning: having a first- or second degree relative with a history of any psychotic disorder in combination with a deterioration of mental state and/or social functioning in the last year
  • Attenuated psychotic symptoms: presence of psychotic symptoms at sub-clinical level
  • Brief, limited or intermittent psychotic symptoms: having a history of psychotic symptoms with a duration of less than one week and spontaneous remission
  • Multiple Complex Developmental disorder

You may not qualify if:

  • A previous psychotic episode for more than one week
  • Verbal IQ \< 75
  • Symptoms are due to an organic mental disorder or substance abuse

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Medical Center Utrecht, department of Child and Adolescent Psychiatry

Utrecht, Utrecht, Netherlands

Location

MeSH Terms

Conditions

Psychotic Disorders

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic DisordersMental Disorders

Study Officials

  • Patricia Schothorst, PhD

    University Medical Center Utrecht, department of Child and Adolescent Psychiatry

    PRINCIPAL INVESTIGATOR

  • Herman van Engeland, Professor

    University Medical Center Utrecht, department of Child and Adolescent Psychiatry

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
DEFINED POPULATION
Time Perspective
OTHER
Sponsor Type
OTHER

Study Record Dates

First Submitted

September 9, 2005

First Posted

September 16, 2005

Study Start

June 1, 2003

Study Completion

June 1, 2008

Last Updated

April 20, 2007

Record last verified: 2007-04

Locations

NL(1)